SAN FRANCISCO - Bisphosphonates may hold promise for chemoprevention
of colorectal cancer, based on a case-control study conducted in Israel, but randomized trials will be needed to confirm the results.
SAN DIEGO -- Small doses of two historic drugs administered in tandem profoundly reduced the development of colorectal adenomas in patients with prior adenoma formation, heralding a "mid-game home run" in secondary chemoprevention
investigators reported at the annual meeting of the American Association for Cancer Research.
Initial chapters present current thinking on the biology of this cancer that affects some 140,00 Americans each year, from the points of view of chemoprevention
SAN ANTONIO -- Updated results of the world's largest breast cancer treatment trial have injected a cautionary note into efforts to develop the aromatase inhibitors as breast cancer chemoprevention
The purpose of this initiative is to stimulate development and application of biological markers of prostate cancer risk and tumor aggressiveness and for utilization in chemoprevention
These findings also provide a rationale for targeting acetylated STAT3 for chemoprevention
and cancer therapy.
CHICAGO - In the not-too distant future, physicians may be sending patients off to the beach with a bagful of chemoprevention
tricks to outwit ultraviolet radiation and reduce the risk of sun-related skin cancers.
ORLANDO -- Early findings from the Aspirin Esomeprazole Chemoprevention
Trial indicate that therapy with aspirin and esomeprazole is safe and well tolerated for preventing the progression of Barrett's esophagus to adenocarcinoma.
Emerging interventions described include gene therapy, chemoprevention
, and toxicity modification.
If a history of induced abortion predisposed women to this more virulent form of the disease, then more intense screening and/or chemoprevention
might be in order, the physician noted.
Gene expression studies were performed using a commercial cDNA-array from Superarray that contains a limited number of genes (96 genes) related to drug metabolism, and a custom-made cDNA microarray that contains a higher number of genes (300 genes, including some genes from Superarray) related to mechanisms of carcinogenesis or chemoprevention
. Real-time PCR and enzyme activity assays were additionally performed to confirm selected array results.
For example, men identified as high risk might elect to embark on a program of risk reduction through diet and lifestyle modification along with chemoprevention
using finasteride, which has been shown to reduce prostate cancer risk by about 25%.