The PCDDs-induced toxicity includes skin lesions (e.g., chloracne
), endometriosis, teratogenic effects, reproductive effects and carcinogenicity to living organisms [1, 7].
'Dioxins are considered highly toxic and are implicated in weakening the immune system, affecting fetal development and causing a skin disorder called chloracne
,' wrote Cynthia P.
Handling of dioxin measurement data in the presence of non-detectable values: overview of available methods and their application in the Seveso chloracne
and chloracnegens," Journal of the American Academy of Dermatology, vol.
Exactly what did happen was that the prisoners created an eruption of chloracne
(all that things from secondary school integrated with blackheads and cysts and pustules that provided the appearance of the photo shown to the left) that stem on the cheeks, behind the ears, underarms, and the groin-- of course, the groin.
Dioxin causes a form of disfiguring acne called chloracne
; Viktor Yushchenko, the former president of Ukraine, is a well-known sufferer.
Perhaps the clearest, well-documented example of this is where high-level chronic raising of Nrf2 levels by TCDD (dioxin) leads to chloracne
. (51,52) TCDD also has other, Nrf2-independent toxic effects, but these acne-like changes in skin properties are clearly caused by excessive, long-term levels of Nrf2, such that chloracne
may serve as a marker for excessive Nrf2 stimulation.
Category of Evidence Presumption Examples Sufficient evidence of an B-cell leukemia association Chloracne
Limited/suggestive evidence of Prostate cancer an association Diabetes Inadequate/insufficient evidence 1994 assessment for type II to determine whether an diabetes, moved to limited/ association exists suggestive in 2000.
TCDD and other dioxins induce a host of toxic responses in mammals, such as thymic involution, immunosuppression, wasting syndrome, and chloracne
. The aryl-hydrocarbon receptor (AHR) mediates virtually all of these dioxin-induced pathologies [4, 5].
Based on these results, the use of olestra for the treatment of chloracne
associated with dioxins was proposed by Sterling and Hanke .
Non-cancer effects of exposure to large amounts of dioxin include chloracne
, developmental and reproductive effects, damage to the immune system, interference with hormones, skin rashes, skin discoloration, excessive body hair, and possibly mild liver damage.
Common differential diagnoses include infantile acne, familial dyskeratotic comedones (FDC), extensive comedones due to chloracne
and sun damage, dilated pore nevus and porokeratotic eccrine ostial duct nevus.1,2,4 In infantile acne lesions are not linear and are self-limited.