Currently, there is increased use of chloramphenicol
(Chloromycetin[R]), oxytetracycline and neomycin in studies.
Antibiotic discs tested in the study were nalidixic acid (30mcg), tetracycline (30mcg), co-trimoxazole (25mcg), ciprofloxacin (5mcg), chloramphenicol
(30mcg), ampicillin (10mcg), gentamicin (10mcg), nitrofurantoin (300mcg), imipenem (10mcg), meropenem (10mcg), cefotaxime (30mcg) and piperacillintazobactum (100/10mcg) and the values obtained were interpreted as being resistant, intermediate and sensitive according to the Clinical and Laboratory Standards Institute guidelines.
Our results show that xylose increases the antibiotic activity of tetracycline and chloramphenicol
against efflux-dependent resistant A.
The tested antimicrobial drugs were ampicillin, trimethoprim/sulphamethoxazole, chloramphenicol
, nalidixic acid, ciprofloxacin, ofloxacin, levofloxacin, ceftriaxone and cefixime.
 The emergence of antimicrobial resistance, especially the multidrug resistance to ampicillin, chloramphenicol
and co trimoxazole, has further complicated the treatment and management of enteric fever.
For the purpose of their study, the researchers infected mice with a cocktail containing both - Staphylococci bacteria resistant to the antibiotic chloramphenicol
and non-resistant Streptococci.
MRSA was found to be highly susceptible to vancomycin 149 (100%), linezolid 144 (96.7%), minocycline 143 (96.3%) and showed moderate susceptibility to rifampicin 111 (74.7%), fusidic acid 99 (66.7%) and chloramphenicol
For isolation of yeast and fungi, the otitic exudate was inoculated on Sabouraud's dextrose agar (SDA) with Chloramphenicol
slants, incubated at 25[degrees]C and examined every 4-6 days.
According to drug sensitivity patterns, vancomycin was found sensitive in 100%, linezolid 98.9%, mupirocin 96.8%, rifampicin 95.7%, chloramphenicol
94.7%, clindamycin 86.2%, amikacin 84%, moxifloxacin 83%, fusidic acid 79.8%, gentamicin 76.6%, oxacillin 69.1%, ciprofloxacin 68.1%, amoxicillin-clavulanic acid 62.8%, erythromycin 60.6% and trimethoprim- sulphamethaxazole 57.4% of cases.
Given the importance of Thymus species as useful antibacterial remedies, the aim of the present study was to examine the chemical composition and antibacterial effect of the essential oil of Thymus glabrescens (thyme), as well as the association between it and chloramphenicol
. The antibacterial activities of geraniol and thymol, the main active principles of thyme oil, in combination with chloramphenicol
were also determined.
The sensitivit y of drugs like amoxicillin chloramphenicol
and co-trimaxazole were 2.8% 12.3% and 22.6% respectively.
(10,11) An open label, randomised controlled trial found that, compared to immediate antibiotic treatment, delayed prescribing of chloramphenicol
provided a similar severity and duration (mean 3.3 days versus 3.9 days) of symptoms and reduced the likelihood of re-attendance to the practitioner.