Post randomisation, the chlordiazepoxide
sample had 42 patients (40.8%) while 61 patients (59.2%) received lorazepam, the disparity being due to the fact that 10 patients to be included in the chlordiazepoxide
group were given lorazepam due to liver disease corroborated by LFT abnormalities.
The list of potentially inappropriate drugs included propoxyphene, indomethacin, pentazocine, methocarbamol, carisoprodol, oxybutynin, chlorzoxazone, metaxalone, cyclobenzaprine, flurazepam, amitriptyline, doxepin, meprobamate, lorazepam, oxazepam, alprazolam, temazepam, zolpidem, triazolam, chlordiazepoxide
, diazepam, hydroxyzine, promethazine, all barbiturates (except phenobarbital), and meperidine.
Iorazepam 2-6 mg every 1-4 hours diazepam 10-20 mg every 1-3 hours for first three doses chlordiazepoxide
25-100 mg every 1-2 hours as needed BARBITURATES phenobarbital 60-90 mg t.i.d.
and the moderation of the initial response to reward reduction.
was synthesized and marketed in the United States in 1961.
(2) Hepatotoxicity with benzodiazepines is infrequent, with a few cases of cholestatic injury reported with diazepam, chlordiazepoxide
, and flurazepam.
Among the long-acting drugs, chlordiazepoxide
and diazepam are preferred.
We examined its utility in a recent series of experiments in which conditioned suppression (of lever pressing by rats) was modified by acute or chronic treatment with an anxiolytic (chlordiazepoxide
) or an anticonvulsant that acts at the GABA/benzodiazepine receptor complex (valproate), or by one of these drugs in combination with a possible antagonist.
(1-5) For patients who have been taking alprazolam or clonazepam, 1 mg, the equivalent diazepam dosage would be 20 mg; for temazepam, 30 mg, the diazepam dosage would be 15 mg; for lorazepam, 1 mg, oxazepam, 20 mg, or chlordiazepoxide
, 25 mg, the diazepam dosage would be 10 mg.
(CDP) and related benzodiazepine compounds consistently reduced defensive or anxiety-like responses in wild and laboratory rodents over a wide range of testing situations (e.
Since the discovery of chlordiazepoxide
in the 1950s, benzodiazepines have revolutionized the treatment of anxiety and insomnia, largely because of their improved safety profile compared with barbiturates, formerly the preferred sedative-hypnotic.