The drugs were categorized into 5 distinct groups: metformin, glyburide, thiazolidinediones (pioglitazone, rosiglitazone), insulin and other oral hypoglycemic agents (chlorpropamide
, gliclazide, tolbutamide, glimepiride, sitagliptin, saxagliptin, nateglinide, repaglinide).
apocynaceae (Madagascar periwinkle) and chlorpropamide
(Diabenese) on alloxan-induced diabetic rats.
Remko  used the methods of theoretical chemistry to elucidate the molecular properties of the hypoglycemic sulfonylureas and glinides (acetohexamide, tolazamide, tolbutamide, chlorpropamide
, gliclazide, glimepiride, glipizide, glibenclamide, nateglinide, and repaglinide) which are known as antidiabetic molecules.
A wide variety of drugs are associated with SIADH, including chlorpropamide
, clofibrate, carbamazepine, vincristine, selective serotonin reuptake inhibitors, tricyclic anti-depressants, and NSAIDs .
Six drugs are included in this subclass: chlorpropamide
, glimepiride (Amaryl), glipizide (Glucotrol), glyburide, tolazamide (Tolinase), and tolbutamide.
Traditional sulfonylureas such as chlorpropamide
and glibenclamide, are either obsolete or rarely used now.
The urinary clearance of methotrexate, phenobarbital, chlorpropamide
, and fluoride is increased after reaching urinary pH levels of 7.5-8.0 via formation of lipid insoluble metabolite of the parent drug.
There are some cases in literature reporting use of alternative treatments like carbamazepine , chlorpropamide
[21,22], and clofibrate [21, 23] for management of central diabetes insipidus.
The second large body of evidence came from the 10-year follow-up of the UKPDS, whereby subjects initially randomized to the intensive glucose arm and who received the SUs chlorpropamide
, glibenclamide, or glipizide had reduction of 15% in MI and 13% in overall mortality compared to the conventional group .
Sulfonylureas (e.g., chlorpropamide
[Diabinese[R]]) should be avoided in Stages III-V renal disease.
Simulate beta cells to (Diabenase[R]) release more insulin.
Inciting medications are often one of the following: chloramphenicol, ethambutol, isoniazid, digitalis, chloroquine, streptomycin, chlorpropamide
, ethchlorvynol, disulfiram, methanol, carbondioxide, amiodaroneandmetals such as lead.