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A long-acting sulfonylurea drug, C10H13ClN2O3S, used to treat type 2 diabetes.

American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.


(Pharmacology) a sulfonylurea drug that reduces blood glucose and is administered orally in the treatment of diabetes mellitus. Formula: C10H13ClN2O3S
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014
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The drugs were categorized into 5 distinct groups: metformin, glyburide, thiazolidinediones (pioglitazone, rosiglitazone), insulin and other oral hypoglycemic agents (chlorpropamide, gliclazide, tolbutamide, glimepiride, sitagliptin, saxagliptin, nateglinide, repaglinide).
apocynaceae (Madagascar periwinkle) and chlorpropamide (Diabenese) on alloxan-induced diabetic rats.
Remko [16] used the methods of theoretical chemistry to elucidate the molecular properties of the hypoglycemic sulfonylureas and glinides (acetohexamide, tolazamide, tolbutamide, chlorpropamide, gliclazide, glimepiride, glipizide, glibenclamide, nateglinide, and repaglinide) which are known as antidiabetic molecules.
A wide variety of drugs are associated with SIADH, including chlorpropamide, clofibrate, carbamazepine, vincristine, selective serotonin reuptake inhibitors, tricyclic anti-depressants, and NSAIDs [3].
Six drugs are included in this subclass: chlorpropamide, glimepiride (Amaryl), glipizide (Glucotrol), glyburide, tolazamide (Tolinase), and tolbutamide.
Traditional sulfonylureas such as chlorpropamide and glibenclamide, are either obsolete or rarely used now.
The urinary clearance of methotrexate, phenobarbital, chlorpropamide, and fluoride is increased after reaching urinary pH levels of 7.5-8.0 via formation of lipid insoluble metabolite of the parent drug.
There are some cases in literature reporting use of alternative treatments like carbamazepine [20], chlorpropamide [21,22], and clofibrate [21, 23] for management of central diabetes insipidus.
The second large body of evidence came from the 10-year follow-up of the UKPDS, whereby subjects initially randomized to the intensive glucose arm and who received the SUs chlorpropamide, glibenclamide, or glipizide had reduction of 15% in MI and 13% in overall mortality compared to the conventional group [20].
Sulfonylureas (e.g., chlorpropamide [Diabinese[R]]) should be avoided in Stages III-V renal disease.
Sulfonylureas Chlorpropamide Simulate beta cells to (Diabenase[R]) release more insulin.
Inciting medications are often one of the following: chloramphenicol, ethambutol, isoniazid, digitalis, chloroquine, streptomycin, chlorpropamide, ethchlorvynol, disulfiram, methanol, carbondioxide, amiodaroneandmetals such as lead.