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A salt or ester of cholic acid.

American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.


(Chemistry) a cholic acid salt
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014


(ˈkoʊ leɪt)

the salt form of cholic acid.
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
References in periodicals archive ?
* Cholate. Sinful high fat ice cream almost like a marquise, Morena is made of pure Malagos chocolate.
perfringens in Duncan and Strong [19] medium containing 0.3 to 6.5 mM sodium cholate or sodium deoxycholate, found that direct spore counts declined only in concentrations of 3.5-6.5mM sodium cholate and deoxycholate, but found that concentrations of >1.2 mM deoxycholate reduced the count of heat-resistant spores.
stearothermophilus was stable towards a variety of surfactants (i.e., Tween-20, Tween-80, Triton-X100, and SDS), anionic detergent (i.e., sodium cholate, sodium taurocholate), and oxidizing agents (i.e., [H.sub.2][O.sub.2], sodium perborate, and sodium hypochlorite) in which more than 82% of its relative activity was retained [26].
Methylene chloride (C[H.sub.2][Cl.sub.2], DCM), sodium cholate (SC), Nile Red, 4% paraformaldehyde, phosphate buffer saline (PBS), and other chemical reagents were laboratory grade and obtained from WAKO (Tokyo, Japan).
This hypothesis is further supported by previous investigations, in which the intravenous injections of cholate glucuronide to rats resulted in a rapid and efficient secretion in bile of the unchanged glucuronide conjugate [31].
Major strengths of the study are the large sample size and long-term nearly ad libitum feeding with a fat-, fructose-, and energy-rich diet without confounding cholate, leading to severe abdominal obesity.
1 mg of SWCNTs was dispersed in 10 ml of aqueous solution of 1 wt% sodium cholate (SC) by using a probe-type sonicator (Sonifier 450D, Branson) with an output power of 5 W, for 10 min.
High-fat diet was composed of 68.8% normal diet, 15% sugar, 10% lard, 5% egg yolk powder, 1% cholesterol, and 0.2% sodium cholate. After one week of adaptive feeding, the mice were fed with high-fat diet except for the normal control group.
Sodium laurate and cetyl alcohol, sodium cholate, ethylenediaminetetraacetic acid (EDTA), ZO toxin (ZOT), cyclodextrin, dextran sulfate, azone, esters, crown ethers, sucrose esters, and phosphotidyl choline are other absorption enhancers usable for the oral delivery of proteins and peptides (11, 20).
Most identified enhancers can be classified as: alcohols (ethanol, pentanol, benzyl alcohol, lauryl alcohol, propylene glycols and glycerol), fatty acids (oleic acid, linoleic acid, valeric acid and lauric acid), amines (diethanolamine and triethanolamine), esters (isopropyl palmitate, isopropyl myristate and ethyl acetate), amides (1-dodecylazacycloheptane-2-one [AzoneA(r)], urea, dimethylacetamide, dimethylformamide and pyrrolidone derivatives), hydrocarbons (alkanes and squalene), surfactants (sodium laureate, cetyltrimethylammonium bromide, BrijA(r), TweenA(r) and sodium cholate), terpenes (D-limonene, carvone and anise oil), sulfoxides (dimethyl sulfoxide) and phospholipids (lecithine).
The Strain pronounced the survival rate of more than 90% in 1.% of bile salt (sodium deoxy cholate) and was used for further studies.
The interference or obstruction on an important metabolic pathway of hepatocytes or any step in synthesis or secretion of bile caused by metabolites of drugs can induce cholestasis.[sup][13] On the cellular level, the main influences on bile secretion from drugs include cell receptors carrying cholate, fluidity of cell membrane, activity of Na[sup]+ -K[sup]+ -ATP enzyme, ion exchange, integrity changes of cytoskeleton, and cell lipid membrane.