cholestasis


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cho·le·sta·sis

 (kō′lĭ-stā′sĭs)
n.
Suppression of biliary flow.

cho′le·stat′ic (-stăt′ĭk) adj.

cholestasis

(ˌkəʊlɪˈsteɪsɪs)
n
(Pathology) the medical condition characterized by the inability of bile to pass normally out of the liver due to blockage or impairment

cho•le•sta•sis

(ˌkoʊ ləˈsteɪ sɪs, -ˈstæs ɪs, ˌkɒl ə-)

n.
impairment of the flow of bile.
[1930–35]
cho`le•stat′ic (-ˈstæt ɪk) adj.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.cholestasis - a condition in which little or no bile is secreted or the flow of bile into the digestive tract is obstructedcholestasis - a condition in which little or no bile is secreted or the flow of bile into the digestive tract is obstructed
disorder, upset - a physical condition in which there is a disturbance of normal functioning; "the doctor prescribed some medicine for the disorder"; "everyone gets stomach upsets from time to time"
Translations

cho·le·sta·sis

, cholestasia
n. colestasis, estasis biliar.

cholestasis

n colestasis f; intrahepatic — of pregnancy colestasis intrahepática del embarazo
References in periodicals archive ?
Recent data from Mirum's lead asset maralixibat in the pediatric liver diseases Alagille syndrome, or ALGS, and progressive familial intrahepatic cholestasis, or PFIC, suggest the mixed results from prior studies were a result of underdosing, Seedhouse said in a Monday initiation note.
Albireo's lead product candidate, odevixibat (A4250), is being developed to treat rare pediatric cholestatic liver diseases and is in Phase 3 development in its initial target indication, progressive familial intrahepatic cholestasis. Albireo's clinical pipeline also includes two Phase 2 product candidates.
7, 2019 (HealthDay News) -- For women with intrahepatic cholestasis of pregnancy, treatment with ursodeoxycholic acid does not reduce adverse perinatal outcomes, according to a study published online Aug.
In a paper published in the journal 'The Lancet', it was found that 605 pregnant women with intrahepatic cholestasis of pregnancy (ICP) were recruited with half receiving ursodeoxycholic acid (known as 'urso'), the current drug used to treat the condition, and half a placebo.
Biopharmaceutical company Mirum Pharmaceuticals stated on Tuesday that it has dosed the first paediatric patient with progressive familial intrahepatic cholestasis (PFIC) under the Phase 3 MARCH-PFIC clinical trial of its lead drug candidate maralixibat, with topline results in fourth quarter of 2020.
The odevixibat PEDFIC program in progressive familial intrahepatic cholestasis, PFIC, consists of two clinical trials.
She was delivered at 40 weeks gestation with a birth weight of 2020 g and presented at two weeks of life with significant neonatal cholestasis. She had persistent jaundice and mild hepatomegaly with laboratory investigations showing evidence of conjugated hyperbilirubinemia [peak conjugated bilirubin 193 micromol/L, (normal range: 0-2 micromol/L)] and marked elevation of liver enzymes [peak aspartate aminotransferase (AST): 3633 U/L, (normal range: 0-110 U/L), peak alanine aminotransferase (ALT): 2120 U/L, (normal range: 0-60 U/L) and peak gamma-glutamyl transferase: 106, (normal range: 0-45 U/L)].
IFALD results in hyperbilirubemia, steatosis, cholestasis, and hepatic fibrosis (Onishi et al., 2016).
Arthrogryposis, renal tubular dysfunction, cholestasis (ARC) syndrome was originally described in 1973 by Lutz-Richner and Landolt (1) severe growth retardation, ichthyosis, recurrentfebriledisease, plateletabnormalities, sensorineural hearing loss, hypotonia and corpus callosum dysgenesis were later included as further features of the syndrome (1,2).
Neonatal cholestasis (NC) is a rare clinical condition characterized by decreased bile drainage and direct hyperbilirubinemia (1).
Persistent neonatal cholestasis is a major clinicopathological concern affecting almost1 in 2500 infants and is an important diagnostic challenge1.
Vikki Meredith suffered from a liver condition called intrahepatic cholestasis of pregnancy (ICP), and as a result had one of the worst cases of itching.