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Related to cholinergic neurotransmission: acetylcholine, cholinergic neurotransmitter


1. Activated by or capable of liberating acetylcholine, especially in the parasympathetic nervous system.
2. Having physiological effects similar to those of acetylcholine: a cholinergic agent or drug.

[(acetyl)cholin(e) + -ergic.]

cho′li·ner′gi·cal·ly adv.


1. (Physiology) denoting nerve fibres that release acetylcholine when stimulated
2. (Physiology) of or relating to the type of chemical activity associated with acetylcholine and similar substances
[C20: from (acetyl)cholin(e) + Greek ergon work]


(ˌkoʊ ləˈnɜr dʒɪk, ˌkɒl ə-)

1. resembling acetylcholine in physiological effect: a cholinergic drug.
2. releasing acetylcholine: a cholinergic neuron.
3. activated by acetylcholine: a cholinergic receptor.
[1930–35; (acetyl) choline + -ergic]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Adj.1.cholinergic - releasing or activated by acetylcholine or a related compound
anticholinergic - inhibiting or blocking the action of acetylcholine at a receptor site; "anticholinergic drugs"
References in periodicals archive ?
In addition, cholinergic neurotransmission in the rat medial prefrontal cortex was found to be enhanced by treatment with GBE and its flavonol derivatives (Kehr et al.
A battery of biomarkers was investigated in clam gills, including histomorphological endpoint, cholinergic neurotransmission, oxidative stress, and hypoxia biomarkers.
Recently, Liu (2014) has shown the role of cholinergic neurotransmission, via the activation of the acetylcholine receptor alpha7, in the mediation of the conditioned incentive properties of external nicotine cues, for which reason manipulating the activity of the acetylcholine receptor alpha7 could be a target in the development of drugs to prevent relapse brought on by outward cues.
7,8] The authors integrate a small but growing literature with findings from their own studies to suggest that cholinergic neurotransmission at nicotinic receptors is essential to normal brain circuit development and, more importantly, that choline supplementation in the second and third trimesters is associated with improved inhibitory neuronal functions--functions that are associated with schizophrenia and attention deficit disorder.
7 Previous studies also reveal that salbutamol inhibits vagally-mediated cholinergic neurotransmission through heterogeneous AY2 receptors and inhibits acetylcholine release.
Cholinergic neurotransmission plays a key role in many physiological processes in the central nervous system, ranging from learning and memory formation to fine control of sleep-wake cycles (SWC).
Although they cannot be detected prior to autopsy, characteristic pathologic features of this disease include neurofibrillary tangle and plaque formation and changes in oxidative and inflammatory processes as well as cholinergic neurotransmission.
Cholinergic neurotransmission and acetylcholinesterase (AChE; a vital functional enzyme in cholinergic neurotransmission) play important roles in multiple advanced brain functions, such as memory, learning, and attention (Hasselmo and Sarter 2011; reviewed by Soreq and Seidman 2001 and by Woolf and Butcher 2011).