Scopolamine butylbromide is a synthetic, peripheral cholinergic receptor
blocker that ameliorates the hyperreactivity of cholinergic receptors
in the preganglionic sympathetic neurons and reduces the overcontraction of visceral smooth muscles.
It is also an intermediate of the phosphatidylinositol cycle, a second-messenger neuronal signaling system used by noradrenergic, serotonergic, and cholinergic receptors
The drug's binding profile is marked by high affinity and selectivity for 5-HT2A receptors, a feature that appears to be effective for treating PD psychosis, with no appreciable affinity for adrenergic, dopaminergic, histaminergic, or cholinergic receptors
We used Scop to promote amnesia in the animals because it has been shown to impair memory by blocking the muscarinic cholinergic receptors
in the brain (Giovannini et al.
During pregnancy, nicotine stimulates nicotinic cholinergic receptors
in the placenta and fetus, resulting in various deleterious effects.
The first section discusses both general mechanisms acting on voltage-gated sodium and potassium channels and cholinergic receptors
and specific mechanisms of palytoxin, maitotoxin, domoic acid, azaspiracids, and yessotoxins.
Overstimulation of nicotinic cholinergic receptors
at neuromuscular junction results in depolarization blockade.
9] The medications act on the autonomic nervous system by blocking peripheral adrenergic receptors and cholinergic receptors
which results in hypotension, tachycardia, urinary incontinence and other symptoms of autonomic nervous system dysfunction.
HET] mice have reduced ACh transmission by central cholinergic neurons (22), compensatory mechanisms, such as supersensitivity of cholinergic receptors
, could account for the normal sleep-wake physiology.
3]H]Propylbenzilylcholine mustard-labeling of muscarinic cholinergic receptors
that selectively couple to phospholipase C or adenylate cyclase in two cultured cell lines.
The intraperitoneal administration of scopolamine, a specific antagonist for the muscarinic cholinergic receptors
, in a dose of 0.
1] carbachol (n = 30), the latter an agonist of ionotropic and metabotropic cholinergic receptors
, were detected in oocytes injected with membranes from the squid stellate ganglia.