chordoma

(redirected from chordomas)
Also found in: Medical, Encyclopedia.
Related to chordomas: chondrosarcomas

chordoma

a rare congenital tumor of the brain.
See also: Cancer
Mentioned in ?
References in periodicals archive ?
Clival chordomas are challenging targets to surgeons because of their critical location, invasive nature, and tendency for aggressive recurrence.
Chordomas are malignant tumors originating from embryonic notochord remnants in the craniospinal axis, mostly the sacrococcygeal (50 percent) and the spheno-occipital regions (35 percent), though 15 percent can occur in the true vertebrae.
Postoperative proton therapy for chordomas and chondrosarcomas of the spine: adyuvant versus salvage radiation therapy.
They address the definition, history, demographics, pathology, and pathogenesis, including molecular biology, cytogenics, and local invasion and metastasis; diagnosis, including radiologic findings, differential diagnosis, and molecular imaging; surgical treatment approaches for tumors in various areas; and special topics, such as radiation, charged particle beams, stereotactic radiosurgery, recurrence, outcomes and quality of life, and chordomas in children.
Chordomas are rare bone tumors that arise from notochord remnants.
1,2 Cases of extra-axial chordomas have also been reported.
Much rarer primary tumors are schwannomas of other cranial nerves: of the trigeminal nerve, of the facial nerve, or of the caudal cranial nerves; paragangliomas, chordomas, chordosarcomas, arachnoid or neurenteric cysts, dermoid tumors, and metastases5.
Dedifferentiated chordoma, meanwhile, is a fatal variant of conventional chordoma that is even rarer, occurring in only 2%-8% of all chordomas.
Chordomas are tumors that arise from the osseous spine and skull base and comprise 2-4% of all bone cancers.
Recent studies have shown the transcription factor steroidogenic factor 1 is an extremely sensitive marker at identifying adrenal cortical neoplasms (ranging from 85% to 100%) and, furthermore, exhibits 100% specificity at discriminating these neoplasms from other tumors with clear cell morphology, such as renal cell carcinoma, ovarian clear cell carcinoma, and chordomas (176,177) This nuclear marker is identified at high levels in sex cord-stromal tumors of the ovary and at lower levels in testicular sex cord-stromal tumors.
INTRODUCTION: Chordomas are generally slow growing malignant neoplasms of presumed notochordal origin.