(41.) Lazorthes Y, Sagen J, Sallerin B, Tkaczuk J et al, "Human Chromaffin
Cell Graft into the CSF for Cancer Pain Management: A Prospective Phase II Clinical Study", Pain, 2000, Jul.; 87(1): 19-32.
The hypothesis is that bovine adrenal chromaffin
cells express multiple subtypes that can be identified using receptor protection assays.
Cells for Chronic Pain After Spinal Cord Injury" Mary J.
Serotonin is present in large concentrations in the chromaffin
tissues of the intestine and other abdominal structures.
SCG neurons are lineally related to adrenal medullary chromaffin
Nav1.7 sodium channel-induced Ca2+ influx decreases tau phosphorylation via glycogen synthase kinase-3beta in adrenal chromaffin
A patch clamp study of the nicotinic acetylcholine receptor of bovine adrenomedullary chromaffin
cells in culture.
Pheochromocytoma is a rare neoplasm arising from chromaffin
cells in the adrenal medulla and is characterized by increased catecholamine synthesis and release.
Radiation, chemotherapy and other toxins release 5-HT from chromaffin
cells in the gut, which stimulates vagal afferents -a process inhibited by the 5-H[T.sub.3] antagonist antiemetics.
These tumors arise in the chromaffin
cells of the adrenal medulla, although they could arise extra-adrenally as well.
Pheochromocytoma (PHEO; MIM #171300) is a rare neuroendocrine tumor of chromaffin
cells originating in the adrenal medulla, whereas paragangliomas (PGLs; MIM #168000) are even rarer tumors arising in the paraganglia along the parasympathetic and sympathetic chains .
Nicotine promotes release of Epinephrine from adrenal gland and other chromaffin
tissue and norepinephrine from hypothalamus and adrenergic synapses.