Despite advances on the outcome of patients with advanced kidney cancer using new targeted therapies, optimal treatment for non-clear cell varieties such as papillary, chromophobe
, collecting duct cancers still remains uncertain.
The differential diagnosis of oncocytic tumors on resections includes an oncocytoma; an eosinophilic variant of chromophobe
renal cell carcinoma; a low-grade renal cell carcinoma with oncocytic features, unclassified type; a succinate dehydrogenase (SDH)-deficient renal cell carcinoma; and a hybrid oncocytic tumor.
6%) had chromophobe
cell carcinoma, three patients (2.
7) Other histological variants such as papillary, chromophobe
, oncocytoma, collecting duct, or unclassified are less common.
cell carcinoma accounts for only 3-5% of all RCCs and carries a better prognosis than clear cell RCC.
Genomics of chromophobe
renal cell carcinoma: Implications from a rare tumor for pan-cancer studies.
Other types include papillary (15%), chromophobe
(5%), collecting duct (1%) and unclassified (4%).
mRNA expression, somatic mutation, and the DNA methylation data of 13 cancer types [bladder urothelial carcinoma (TCGA ID: BLCA), breast invasive carcinoma (BRCA), colon adenocarcinoma (COAD), head and neck squamous cell carcinoma (HNSC), kidney chromophobe
renal cell carcinoma (KICH), kidney renal clear cell carcinoma (KIRC), kidney renal papillary cell carcinoma (KIRP), lung adenocarcinoma (LUAD), lung squamous cell carcinoma (LUSC), prostate adenocarcinoma (PRAD), rectum adenocarcinoma (READ), stomach adenocarcinoma (STAD), and thyroid carcinoma (THCA)] were collected from the TCGA data portal (https://tcga-data.
Li, "Metachronous contralateral testicular and bilateral adrenal metastasis of chromophobe
renal cell carcinoma: a case report and review of the literature," Journal of Zhejiang University Science B: Biomedicine & Biotechnology, vol.
HNot many is probably the answer: Barbie's favourite colour evokes everything from mild dislike to outright fear, but even the most ardent chromophobe
will be rethinking their stance when they clap eyes on the rose-tinted AW15 collections.
RCC (CH- RCC) is the third most common subtype, comprising approximately 5% of all RCCs.
The Rosetta Kidney Cancer Test accurately classifies the four most common kidney tumors: clear cell renal cell carcinoma (RCC), papillary RCC, chromophobe
RCC and oncocytoma.