Apart from the 2 most common benign tumors--oncocytoma and angiomyolipoma--the first group includes the 5 most common types of RCC: clear cell, papillary, chromophobe
, clear cell papillary, and unclassified RCCs.
Pathologic features of the cases (n) (%) TNM stage T1a 76 (60.31) T1b 37 (29.36) T2a 13 (10.31) Pathology RCC Clear cell 83 (65.87) Papillary 11 (8.73) Chromophobe
6 (4.76) Oncocytoma 12 (9.52) Angiomyolipoma 14 (11.11) Fuhrman grade 1 36 (28.57) 2 80 (63.49) 3 10 (7.93) Positive 4 (3.17) surgical margin TNM: tumor-node-metastasis classification: RCC: Renal cell carcinoma
According to Hes O, Michal M the presence of GHG in a renal tumour may be of aid for excluding a diagnosis of chromophobe
RCC or oncocytoma.
Renal Cell Carcinoma Histology Type Incidence Clear cell carcinoma 70% to 80% Papillary 10% to 15% Chromophobe
3% to 5% Collecting duct carcinoma <1% Unclassified 1% to 3% Renal medullary carcinoma Rare Source: Campbell & Lane, 2016.
Among them, renal oncocytoma and chromophobe
renal cell carcinoma (RCC) originate from intercalated cells in the collecting duct and share some morphologic, histologic, electron microscopy findings, and immunohistochemical characteristics (2, 3).
According to the colors after HE staining, the cells could be divided into chromophobe
cells, acidophil cells and basophil cells.
MicroRNA expression profiles predict clinical phenotypes and prognosis in chromophobe
renal cell carcinoma.
and papillary RCC type 1 portend a better prognosis.
Papanastasiou MRI-pituitary adenoma Chromophobe
pituitary et al.
In contrast, patients in the young group were more likely to have chromophobe
histology as compared with patients in the young-old or old-old groups (17.1%, 5.4%, and 4.1%, respectively; p< 0.001).
Differential diagnoses included primary clear cell carcinoma of the parotid gland, metastatic disease of the thyroid gland and the kidney including subtypes (clear cell carcinoma, papillary carcinoma, and chromophobe
carcinoma), renal cell adenoma, lymphoma, sarcoma, oncocytoma, and mesenchymal tumours like schwannoma and angioleiomyoma.
Unfortunately, most oncocytomas are difficult to differentiate from chromophobe
renal cell carcinoma due to overlapping ultrastructural, immunohistochemical, and morphological characteristics .