Differential diagnoses included primary clear cell carcinoma of the parotid gland, metastatic disease of the thyroid gland and the kidney including subtypes (clear cell carcinoma, papillary carcinoma, and chromophobe carcinoma
), renal cell adenoma, lymphoma, sarcoma, oncocytoma, and mesenchymal tumours like schwannoma and angioleiomyoma.
miR-1826 had the lowest of all levels in the urine and was foremost expressed in chromophobe carcinoma
with no statistical significance.
Major histopathological subtypes include clear cell carcinoma, papillary carcinoma, chromophobe carcinoma
, collecting duct carcinoma, medullary carcinoma, and unclassified categories .
is typically associated with a favorable prognosis, but aggressive behavior can be seen in a subset, including in hybrid tumors with a higher--grade component.
The 15 TCGA cancer type datasets retrieved included bladder urothelial carcinoma (BLCA), breast invasive carcinoma (BRCA), colon adenocarcinoma (COAD), head and neck squamous cell carcinoma (HNSC), kidney chromophobe carcinoma
(KICH), kidney renal clear cell carcinoma (KIRC), kidney renal papillary cell carcinoma (KIRP), liver hepatocellular carcinoma (LIHC), lung adenocarcinoma (LUAD), lung squamous cell carcinoma (LUSC), prostate adenocarcinoma (PRAD), rectum adenocarcinoma (READ), stomach adenocarcinoma (STAD), thyroid carcinoma (THCA), and uterine corpus endometrial carcinoma (UCEC).
(a) Incidentally identified small solid nodule of the left kidney (red arrow) on abdominal CT scan; (b) Percutaneous US-guided 18 G needle biopsy (green arrow) revealed a chromophobe carcinoma
; (c) Percutaneous radiofrequency was performed and three-months MRI (blue-blue coloured) compared to preoperative CT scan (orange-coloured) showed complete ablation.
It has been found [sup] that when comparing benign and malignant renal lesions on contrast-enhanced CT, RCCs and RO are greatly enhanced in the parenchymal phase, whereas chromophobe carcinoma
and lipid-poor angiomyolipoma are moderately enhanced and papillary tumors are the least enhanced.
(6) In contrast to the notched raisinoid nuclei with detailed chromatin in chromophobe carcinoma
, the degenerative atypia consists of large, often multinucleated cells with smudgy hyperchromatic nuclei and poorly preserved chromatin detail.