chromosomal aberration

Also found in: Thesaurus, Medical, Acronyms, Encyclopedia, Wikipedia.
Related to chromosomal aberration: aneuploidy, gene mutation
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.chromosomal aberration - any change in the normal structure or number of chromosomes; often results in physical or mental abnormalities
aberrance, aberrancy, aberration, deviance - a state or condition markedly different from the norm
monosomy - chromosomal abnormality consisting of the absence of one chromosome from the normal diploid number
trisomy - chrosomal abnormality in which there is one more than the normal number of chromosomes in a cell
sex-linked disorder - any disease or abnormality that is determined by the sex hormones; "hemophilia is determined by a gene defect on an X chromosome"
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
References in periodicals archive ?
Among chromosomal disorders, triploidies are the most commonly observed chromosomal aberration at conception and its frequency may be as high as 1:100 (9).
473: In Vitro Mammalian Chromosomal Aberration Test, OECD Guidelines for the Testing of Chemicals, 1997.
Nevertheless, there are sparse data about chromosomal aberrations induced by being in contact with this herbicide.
Structural anomalies were identified by pathology examination in 109 of the 170 chromosomal aberration specimens (64%).
Briefly, cultures were initiated as described in chromosomal aberration assay and at the end of 44th hour of culture Cytochalasin-B at a final concentration of 3 [micro]g/mL culture was added to each vial.
Abbreviations: CA, chromosomal aberration; MN, micronuclei; chls, cultured human lymphocytes; ROS, reactive oxygen species; DDR, DNA damage response; DMSO, dimethyl sulfoxide; PBS, phosphate buffered saline.
There are several studies demonstrating the suitability of conventional cytogenetic techniques like chromosomal aberration test for the assessment of genotoxic effects of various toxicants using fish as bioindicator.
Implementation of a dose-response curve for gamma-radiation in the Portuguese population by use of the chromosomal aberration assay.
In the present study, the cytogenetic effects of the platinum based anti-tumour drug heptaplatin were analysed by measuring chromosomal aberrations and the mitotic index, in bone marrow cells of SWR/J mice.
They reflect structural or numerical chromosomal aberration. (2)