study of neuro-endocrine axis hormone sequence signalling in healthy men.
We can refer again to the double face of Mel, as a chronobiologic
hormone and as a highly efficient antioxidant and free radical scavenger.
reference values in clinical chemistry.
Not only is saliva testing more accurate, inasmuch as it measures only the active free hormone, but it also allows chronobiologic
testing, which is not feasible with serum testing with its attendant venipunctures.
Studies by our group (10) and others (11) have shown that overattention to mood variation without considering associated cognitive, speech-language, chronobiologic
, and motor signs of mania /hypomania accounts for substantial overdiagnosis of BD in patients with non-specific mood disturbances, particularly in those with active substance abuse or borderline personality disorder (BPD).
With respect to circadian dysregulation, research suggests that chronobiologic
abnormalities, in the form of phase shifts of the core-body temperature rhythm, are related to sleep initiation or maintenance problems (12).
Common triggering events include alcohol consumption, excessive stress, dietary changes, change in sleeping patterns, chronobiologic
changes, and hormonal changes due to menstruation.
In addition, melatonin, a neurohormone with significant chronobiologic
properties, has been quantified in the flowering tops of H.