Retention of fluorescent-labelled chylomicron
remnants within the intima of the arterial wall--evidence that plaque cholesterol may be derived from post-prandial lipoproteins.
14 As a polymorphic protein, ApoE is the ligand of LDL receptor and that of chylomicron
particle receptor in hepatocytes.
3] with APOA4 enter the chylomicron
, then the chylomicron
is exocytosed to the extracellular space and finally enters the blood via lymph transfer.
ApoE was shown to be the ligand that mediates plasma clearance of triglyceride-rich lipoproteins, including VLDL, intermediate-density lipoproteins, and chylomicron
remnants [for review see (1-3)].
Third, it may reduce intestinal secretion of chylomicron
and very low-density lipoproteins (Marcil et al.
Hypertriglyceridaemia in pre-diabetes is due to insulin resistance, which leads to increased hepatic very low density lipoprotein (VLDL) production and defective removal of chylomicrons
remnants that often reflects poor glycaemic control.
A disturbed lipid metabolism happens in patients with CKD "as a result of decreased catabolism of chylomicrons
and lipoprotein particles, remnants of chylomicron
and VLDL accumulate" (Scarpioni, Ricardi, Melfa, & Cristinelli, 2010, p.
remnants are rapidly cleared by liver remnant receptors,  as a result of apolipoprotein E (apoE) acquired in the circulation.
22 showed that LPS can be transported into the blood by mechanisms provided by long chain fatty acids like oleic acid and formation of chylomicron
from intestinal epithelial cells.
The IFP contains these root cells which can transform into adipocyte cells containing chylomicron
and releasing leptin, chondrocyte cells synthesizing the cartilage matrix and osteoblast cells that mineralize, depending on environmental conditions.
Since originally submitting the MAA, AMT has generated significant additional data, including results from a long-term efficacy study of Glybera showing that improved chylomicron
metabolism could be used as a biomarker for increased LPL activity in those patients missing the gene that produces this protein.
The lipoprotein classification includes chylomicron
, very low-density lipoprotein (VLDL), intermediate-density lipoprotein (IDL), low-density lipoprotein (LDL), and high-density lipoprotein (HDL).