cisplatin


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cis·plat·in

 (sĭs-plăt′n, -plā′tn)
n.
A platinum-containing chemotherapeutic drug, Cl2H6N2Pt, used in the treatment of metastatic ovarian or testicular cancers and advanced bladder cancer. Also called cisplatinum.

[Short for cisplatinum.]

cisplatin

(sɪsˈplætɪn)
n
(Pharmacology) a cytotoxic drug that acts by preventing DNA replication and hence cell division, used in the treatment of tumours, esp of the ovary and testis
[C20: from cis- + platin(um)]
Translations

cisplatin

n cisplatino
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References in periodicals archive ?
The present communication demonstrated the proof of concept of hesperidin against cisplatin induced nephrotoxicity.
They hoped that if they added curcumin to the mix, they might be able to lower the Cisplatin dose and cause less organ damage.
El-Mowafy of Mansoura University and associates administered 125 mg/kg of DHA, 250 mg/kg of DHA, cisplatin alone, cisplatin combined with DHA, or a control substance to groups of mice implanted with mammary carcinoma cells.
An unexpected increase in neurotoxicity has been a particular concern, so a less neurotoxic platinum agent, carboplatin, is being investigated as an alternative to cisplatin by the AGO (Arbeitsgemeinschaft Gynakologische Onkologie) study group.
Jude Children's Research Hospital investigators have discovered inherited genetic variations that are associated with rapid hearing loss in young cancer patients treated with the drug cisplatin.
Food and Drug Administration (FDA) has approved Portrazza(TM) (necitumumab injection for intravenous use, 800 mg/50 mL), in combination with gemcitabine and cisplatin, as the first biologic for the first-line treatment of people with metastatic squamous non-small cell lung cancer (NSCLC).
Adding imatinib mesylate to the drug cisplatin blocks the action of a protein that triggers a cascade of events resulting in death of the immature eggs.
In order to deliver cisplatin specifically to tumour cells and to reduce damage to the kidneys, the researchers packaged the drug in nano- particles, which are 600 times smaller than the diameter of a human hair.
In further experimentation, the researchers pretreated ovarian cancer cells with DIM, followed by the administration of cisplatin for 24 hours.
Of these, 70 were treated with gentamicin, 15 with amikacin, and 20 with cisplatin.
Cisplatin is a widely-used chemotherapy drug which damages cancer cells and is used for a number of cancers including those of the cervix, bowel, head and neck and lung.