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cleave 1

v. cleft (klĕft) or cleaved or clove (klōv), cleft or cleaved or clo·ven (klō′vən), cleav·ing, cleaves
1. To split with a sharp instrument. See Synonyms at tear1.
2. To make or accomplish by or as if by cutting: cleave a path through the ice.
3. To pierce or penetrate: The wings cleaved the foggy air.
4. Chemistry To split (a complex molecule) into simpler molecules.
1. To split or be capable or splitting, especially along a natural line of division: Certain brittle woods cleave easily.
2. To penetrate or pass through something, such as water or air.

[Middle English cleven, from Old English clēofan; see gleubh- in Indo-European roots.]

cleav′a·ble adj.

cleave 2

intr.v. cleaved, cleav·ing, cleaves
1. To adhere, cling, or stick fast.
2. To be faithful: cleave to one's principles.

[Middle English cleven, from Old English cleofian.]
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.


(ˈkli və bəl)

capable of being split.
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Adj.1.cleavable - capable of being cleaved
divisible - capable of being or liable to be divided or separated; "even numbers are divisible by two"; "the Americans fought a bloody war to prove that their nation is not divisible"
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
References in periodicals archive ?
Tisotumab vedotin is an ADC composed of Genmab's human antibody that binds to Tissue Factor and Seattle Genetics' ADC technology that utilises a cleavable linker and the microtubule disrupting agent monomethyl auristatin E.
Employing cleavable isotope-coded affinity tags (cICAT) and one-dimensional liquid chromatography (1DLC) coupled with tandem mass spectrometry, Barnidge et al searched for differentially expressed proteins in CLL cells from 2 patients (UM-CLL and M-CLL).
According to the company, Givaudan was the first to introduce, in 2006, a light cleavable fragrance precursor in the palette of ingredients with Scentaurus Tonkarose, a molecule that releases two different odorants.
Korean biotechnology company IntoCell Inc said on Thursday that it has published its patent application in Korea titled "Compounds Comprising Cleavable Linker and Uses Thereof" (Application No.
The current linkers used in ADCs are also broadly classified as cleavable and noncleavable linkers based on where they are cleaved into the cytoplasm.
The posterior and lateral dissection is a brisk process up to the mid-sacral level because of the presence of the loose areolar tissue as the cleavable plane; beyond that level, dissection involves identification and division of a few fascial fibers, vessels, and nerves.
Kidney injury molecule-1 (KIM-1) is a type I transmembrane glycoprotein, located on the apical membrane of dilated proximal tubules with a cleavable ectodomain (90 kDa).
Cured free films of the acrylic latex were placed in a liquid assay with a nucleic acid ester cleavable by the enzyme, thymidine 5-monophosphate p-nitrophenyl ester, and demonstrated degradation of this substrate.
The unique design of the selectively cleavable linker connecting the antibody to the duocarmycin drug leads to high stability in circulation, and induces efficient release of the cytotoxin in the tumor.
Hamedelneil, "Synthesis, characterization and pharmacological evaluation of certain enzymatically cleavable NSAIDs amide prodrugs," Bioorganic Chemistry, vol.
[25] described peri-implantitis/periodontitis online diagnosis utilizing elegantly the tongue as a 24/7 detector allowing diagnosis by "anyone, anywhere, and anytime." Their clever technology utilizes chewing gum-containing peptide sensors as protease cleavable linkers between a bitter taste substance and a microparticle.
The polymerization of MWNTs with PCA starts with the acid-functionalized MWNTs (fMWNT) and is followed by the addition of PCA, which covalently joins carboxylic functional groups of PCA and fMWNTs via a cleavable ester, obtaining polycitric acid-MWNTs (PMWNTs), an interesting material for nanomedicine applications [17,27,28,30,32].