Tisotumab vedotin is an ADC composed of Genmab's human antibody that binds to Tissue Factor and Seattle Genetics' ADC technology that utilises a cleavable
linker and the microtubule disrupting agent monomethyl auristatin E.
isotope-coded affinity tags (cICAT) and one-dimensional liquid chromatography (1DLC) coupled with tandem mass spectrometry, Barnidge et al searched for differentially expressed proteins in CLL cells from 2 patients (UM-CLL and M-CLL).
According to the company, Givaudan was the first to introduce, in 2006, a light cleavable
fragrance precursor in the palette of ingredients with Scentaurus Tonkarose, a molecule that releases two different odorants.
Korean biotechnology company IntoCell Inc said on Thursday that it has published its patent application in Korea titled "Compounds Comprising Cleavable
Linker and Uses Thereof" (Application No.
The current linkers used in ADCs are also broadly classified as cleavable
and noncleavable linkers based on where they are cleaved into the cytoplasm.
The posterior and lateral dissection is a brisk process up to the mid-sacral level because of the presence of the loose areolar tissue as the cleavable
plane; beyond that level, dissection involves identification and division of a few fascial fibers, vessels, and nerves.
Kidney injury molecule-1 (KIM-1) is a type I transmembrane glycoprotein, located on the apical membrane of dilated proximal tubules with a cleavable
ectodomain (90 kDa).
Cured free films of the acrylic latex were placed in a liquid assay with a nucleic acid ester cleavable
by the enzyme, thymidine 5-monophosphate p-nitrophenyl ester, and demonstrated degradation of this substrate.
The unique design of the selectively cleavable
linker connecting the antibody to the duocarmycin drug leads to high stability in circulation, and induces efficient release of the cytotoxin in the tumor.
Hamedelneil, "Synthesis, characterization and pharmacological evaluation of certain enzymatically cleavable
NSAIDs amide prodrugs," Bioorganic Chemistry, vol.
 described peri-implantitis/periodontitis online diagnosis utilizing elegantly the tongue as a 24/7 detector allowing diagnosis by "anyone, anywhere, and anytime." Their clever technology utilizes chewing gum-containing peptide sensors as protease cleavable
linkers between a bitter taste substance and a microparticle.
The polymerization of MWNTs with PCA starts with the acid-functionalized MWNTs (fMWNT) and is followed by the addition of PCA, which covalently joins carboxylic functional groups of PCA and fMWNTs via a cleavable
ester, obtaining polycitric acid-MWNTs (PMWNTs), an interesting material for nanomedicine applications [17,27,28,30,32].