restriction site

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Noun1.restriction site - the specific sites at which a restriction enzyme will cleave DNA
site, situation - physical position in relation to the surroundings; "the sites are determined by highly specific sequences of nucleotides"
site de restriction
References in periodicals archive ?
1 HA genes analyzed possessed a multibasic amino acid cleavage site (Table 1).
125]I]-DEEP, suggesting that binding to the ligand within the protein causes a reorganization of the structure, hiding or exposing a potential trypsin cleavage site.
These amino acids flank the HIV-1 capsid-SP1 cleavage site and the results suggest PA-1050040 may bind differently than bevirimat to this region of the viral Gag protein, which is the target for maturation inhibitor activity.
Like reported avian A(H7N3) virus sequences from Jalisco, the human isolate had a multibasic cleavage site indicative of an HPAI A virus (7) (Figure 2).
76] sequence, at a cleavage site similar to that recognized by the ubiquitous endoprotease furin (7, 8).
Mutation of the proteolytic cleavage site often has profound implications for disease progression (17,18).
To enable rapid construction of variants, 2 new restriction sites, BamHl and EcoRl, flanking the coding region of the activation cleavage site, were introduced in this plasmid by PCR using the following primers: forward, 5'-GATATCAAGGAATTCAGTGGTGTTGATGATGACATGGCG-3'; reverse, 5'-GGATCCTGTCTCAATGCCACAGTCCAG-3'.
The business opportunities presented by the FRS technology, which gives us the ability to solve one of the important problems impeding progress in the oligonucleotide field - how to quickly identify the optimum cleavage site in an RNA molecule - require us to focus our resources on that opportunity.
double dagger]) R(R/K)LM is considered a putative, although unconfirmed, S1P cleavage site.
Protein 2A motifs in THV are conserved with respect to kobuviruses after a predicted cleavage site [Q.
However, based on the knowledge that the G20210A substitution represents in vitro a gain-of-function mutation causing mRNA accumulation and increased protein synthesis (7), creates in vitro but not in vivo a more effective polyadenylation site and cleavage site (7-9), and is proposed to be associated with different mRNA structures leading to abnormal mRNA function (9), it will be worthwhile to initiate additional studies to estimate the impact of this genetic variant on risk assessment for thrombotic events and adverse pregnancy outcomes.