section][section]) Nonstatin lipid-lowering drugs included Niacin, Gemfibrozil, Fenofibric Acid, Clofibrate
, Colesevelam, Colestipol, Cholestyramine, and Cholestyramine/Sorbitol.
Reduction of mortality in the Stockholm ischaemic heart disease secondary prevention study by combined treatment with clofibrate
and nicotinic acid.
There are four classes of lipid-lowering drugs in the market: the 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (the "statins"), the fibrates (gemfibrozil, clofibrate
, and fenofibrate), niacin/nicotinic acid, and the bile acid binding resins (colestipol and cholestyramine).
benziodarone, benzbromarone, fenofibrate, clofibrate
, ibuprofen, WY-14643, gemfibrozil) were randomly distributed across modules in RLV, PHH, and PRH.
For example, peroxisome proliferator-activated receptor [alpha] (PPARA, Figure 3(c)) is the pharmacological target of fibrates such as fenofibrate, clofibrate
, and bezafibrate .
is an activator of peroxisome proliferators-activated receptors (PPARS).
However, when the human TAS1R3 receptor was blocked in the engineered mice by adding the drug clofibrate
to the rodents' diet, thus leaving the mice without any functional TAS1R3 or GNAT3 proteins, the males became sterile due to malformed and fewer sperm.
Fibrate medications include gemfibrozil (Lopid), fenofibrate (TriCor) and clofibrate
Today, the use of synthetic fats and chemical drugs such as Lovastatin, Clofibrate
, Gemfibrozil, nicotinic acid and is widely prevalent in industrialized societies and is urbanized.
Blood HDL levels are dependent on alcohol intake, exercise, drugs such as clofibrate
, nicotinic acids, dietary fat and cholesterol.
was used in a third group and completed the study, but showed no benefit in cardiovascular outcomes.
Estrogen (either in oral contraceptives or for prostate cancer therapy) and clofibrate
(Atromid-S[R]) negates the effects of ursodiol as these medications increase hepatic secretion of cholesterol.