Effect of clofibrate
on prolonged jaundice of term neonates.
When health advice alone was not effective, men in the intervention group also received drugs recommended at that time to lower blood pressure (beta-blockers and diuretics) and lipids (clofibrate
It was led by Professor Michael Oliver of the University of Edinburgh, Scotland, and tested the lipid-lowering drug clofibrate
. The blood cholesterol of 30,000 healthy, middle-aged men from Edinburgh, Prague, and Budapest was analyzed for cholesterol levels.
A wide variety of drugs are associated with SIADH, including chlorpropamide, clofibrate
, carbamazepine, vincristine, selective serotonin reuptake inhibitors, tricyclic anti-depressants, and NSAIDs .
Similar results on insulin/glucagon ratio, due to reduced insulin secretion rather than increase glucagon secretion, after stimulation with arginine, were observed in health subjects  and hypertriglyceridemic patients  treated with 2 grams of clofibrate
for 7 and 2-4 months, respectively.
The synthetic ligands of PPAR[alpha] including fenofibrate, clofibrate
, and wyeth14,643 suppress cancer cell proliferation [2, 5].
([section][section]) Nonstatin lipid-lowering drugs included Niacin, Gemfibrozil, Fenofibric Acid, Clofibrate
, Colesevelam, Colestipol, Cholestyramine, and Cholestyramine/Sorbitol.
Clofibric acid, the active metabolite of clofibrate
(2), is a dual activator of PPAR[alpha] and PPAR[gamma], possessing tenfold selectivity for PPAR[gamma].
Fukushima, "Promoting effect of the peroxisome proliferator, clofibrate
, but not di(2-ethylhexyl)phthalate, on urinary bladder carcinogenesis in F344 rats initiated by N-butylN-(4- hydroxybutyl)nitrosamine," Japanese Journal of Cancer Research, vol.
There are some cases in literature reporting use of alternative treatments like carbamazepine , chlorpropamide [21,22], and clofibrate
[21, 23] for management of central diabetes insipidus.
Popp, "Biomarker evaluation of skeletal muscle toxicity following clofibrate
administration in rats," Experimental and Toxicologic Pathology, vol.