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Related to clonal expansion: Clonal selection


1. A group of cells or organisms that are descended from and genetically identical to a single progenitor, such as a bacterial colony whose members arose from a single original cell.
2. An organism developed asexually from another and genetically identical to it, such as an animal produced from an egg cell into which the nucleus of an adult individual has been transferred.
3. A DNA sequence, such as a gene, that is transferred from one organism to another and replicated by genetic engineering techniques.
4. One that copies or closely resembles another, as in appearance or function: "filled with business-school clones in gray and blue suits" (Michael M. Thomas).
v. cloned, clon·ing, clones
1. To make multiple identical copies of (a DNA sequence).
2. To create or propagate (an organism) from a clone cell: clone a sheep.
3. To reproduce or propagate asexually: clone a plant variety.
4. To produce a copy of; imitate closely: "The look has been cloned into cliché" (Cathleen McGuigan).
To grow as a clone.

[Greek klōn, twig.]

clon′al (klō′nəl) adj.
clon′al·ly adv.
clon′er n.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Adj.1.clonal - of or relating to a clone
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.


[ˈkləʊnəl] ADJclónico
Collins Spanish Dictionary - Complete and Unabridged 8th Edition 2005 © William Collins Sons & Co. Ltd. 1971, 1988 © HarperCollins Publishers 1992, 1993, 1996, 1997, 2000, 2003, 2005
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These potential advantages of our non-viral KOKI technology include: site-specific integration of transgenes into a pre-selected locus in the T cell genome; enhanced clonal expansion of the DAR-T cells; and streamlined method for transgene construct production without need for laborious and time-consuming virus production, release and validation processes, resulting in a shorter research and development timelines for IND-enabling activities."
In England and Wales, the recent increase in IPD due to the nonvaccine serotype 7C was associated with clonal expansion of ST177.
Ouldali said the next step he and his colleagues plan to take is to see if there is a clonal expansion or a particular underlying genetic pattern which could explain the explosive emergence of 24F.
These innate-like T cells rapidly respond to pathogens and display effector functions without undergoing extensive clonal expansion. An understanding of T cell differentiation and function in infectious diseases, as well as their underlying mechanisms, may contribute to the development of potential therapies for emerging infectious diseases in the future.
As per this concept, a single cell is transformed and gives rise to one large, extended, premalignant field by clonal expansion, and gradual replacement of normal mucosa by atypical ones.
For calculating clonal expansion, the count of each mutant was determined by multiplying the percentage of reads containing each unique mutation by the number of plaques sequenced for that animal; because we observed high variability among low numbers of mutant counts, we applied a limit of detection/linear model to correct the counts (Beal et al.
After the differentiation of 3T3-L1 preadipocytes was induced with a medium containing insulin, the cells undergo several rounds of mitosis referred to as mitotic clonal expansion at an early event of differentiation [15,16], A transcription factor, CCAAT/enhancer binding protein (C/EBP)-[beta], is required for the mitotic clonal expansion [15], After mitotic clonal expansion, the preadipocyte cells express the key transcription factor, PPAR[gamma], for adipocyte differentiation, which plays essential roles for inducing the adipocyte specific PPAR-[gamma] target genes such as Glut-4 and fatty acid binding protein [10], The 3T3-L1 cells gradually increase lipid droplet size and number during the differentiation process.
The definition of the relationship between "endosteal SCN," where HSC are maintained, and "vascular SCN," where HSC commitment to differentiation and HPC clonal expansion are driven, was completed much later [7, 8].
Plasma cell neoplasms result from clonal expansion of plasma cells which produce large amount of M-protein, with plasma cell myeloma being the most common disorder of plasma cell dyscrasias [1].
EBV infection promotes survival of B-cells which subsequently undergo clonal expansion. Proliferation of B-cells may ultimately lead to development of a secondary malignant B-cell lymphoma [6, 7].
While such re-assortment is essentially random in nature and thus constantly samples a wide range of "sequence space" or potential binding surfaces, those individual B and T cells whose recombinant markers find a "non-self" match are positively selected for and undergo clonal expansion as the basis for cell-mediated immunity.