The activated clotting time
test is used extensively in cardiovascular surgery, cardiac catheterization labs (angiography and angioplasty) and other critical care settings to monitor patients on heparin therapy.
The role of the activated clotting time
in heparin administration and neutralization for cardiopulmonary bypass.
PolyMedix has conducted animal studies that have shown that a single administration of PMX- 60056 following heparin or LMWH can completely normalize blood clotting time
in the animal subjects.
Such low-molecular-weight heparins are currently used clinically for patients with deep venous thromboembolism and cannot be monitored by clotting time
-based assays such as ACT [201 or activated partial thromboplastin time , since they do not increase clotting times
Relative ease of clinical trials - the primary endpoint is not disease related, but is expected to be demonstration of normalization of blood clotting time
As the in vivo concentration of antithrombin drug increases, the clotting time
increases in a linear dose-dependent manner with essentially no effect of heparin on the clotting time
end point, a potentially important clinical consideration when determination of only the anticoagulant effects of the direct thrombin inhibitor is desired.
It provides accurate and convenient measurement of blood clotting time
, or PT/INR values.
Point-of-care clotting time
devices have recently emerged and offer some economic advantages over current laboratory-based devices .
Total quantity or scope: 1) Defibrillator - 2 pcs, 2) renal replacement therapy device with disposable materials - 2 units, 3) Apparatus for measuring the clotting time
of disposable materials-2 units, 4) to monitor hemodynamic measurements - 1 pc 5) Apparatus for general anesthesia - 1 pc 6) surgical diathermy-1 set, 7) Surgical Diathermy - 1 set, 8) Headlamp - 4 pieces, 9) Surgical Diathermy-1 set
All patients on anticoagulant medication need a prescription from their doctor for a self-testing meter and supplies before being able to monitor their own clotting time
The HemoSense product, the INRatio System, measures the patient's blood clotting time
to ensure that patients with a propensity to form clots are maintained within the therapeutic range with the proper dosage of oral anticoagulant therapy.
Xarelto-induced inhibition of thrombin generation and prolongation of both prothrombin time and activated clotting time
were also partially reversed by andexanet alfa in a dose-dependent manner.