Janet Coates, 64, was found to have three times the typical dose of the Clozapine
drug in her blood when she died in November 2016.
SAN DIEGO -- The atypical antipsychotic drug clozapine
is the standard of care for patients with treatment-resistant schizophrenia, but about half do not see an adequate response, according to Randall F.
B, age 60, has schizophrenia, which has been stable on clozapine
for 2 decades when she is diagnosed with cancer.
Myocarditis occurs more frequently during clozapine
(CLZ) administration than with any other typical or atypical antipsychotic drugs (APs) (1).
Summary: We reported that a female patient occurred serious side effects in the treatment of antipsychotic drug, clozapine
and chlorpromazine, and then appeared withdrawal reactions after she suddenly withdrew clozapine
is an atypical antipsychotic drug that achieves therapeutic efficacy through serotonin-dopamine antagonism.
However, the first randomized double-blind controlled clinical trial on safety and efficacy of clozapine
in PD patients yielded negative results .
is superior to standard antipsychotic drugs in the treatment of patients with refractory schizophrenia.
Pharmaceutical company Mylan NV (Nasdaq:MYL)(TASE:MYL) reported on Tuesday the availability of Clozapine
Orally Disintegrating Tablets, 25 mg and 100 mg in the US market.
In fact, studies conducted worldwide have shown that clozapine
prescription is less than the actual number of patients resistant to the antipsychotic treatment (9).
The patient was being treated with clozapine
, a third-line antipsychotic used for patients who have not responded to first or second-line antipsychotic treatments.
is an atypical antipsychotic medication which displays affinity for a number of receptors in the brain including dopamine, serotonin 5HT1A, 5HT2C, norepinephrine ai and [alpha]2, muscarinic acetylcholine and histamine Hi receptors .