[5-8] Many substances can act as primary pollutants, irritants and carcinogenic or
cocarcinogenic compounds.
Capsaicin also has a
cocarcinogenic effect on TPA-promoted skin carcinogenesis in vivo ; this is mediated through the transient receptor potential vanilloid subfamily number 1 and the tyrosine kinase epidermal growth factor receptor.
Vanillin consumed orally had no effect on ACF; however, when administered through intraperitoneal injection at higher concentration vanillin was
cocarcinogenic, which could well increase ACF density and multiplicity.
The authors concluded that the study showed a
cocarcinogenic effect of lifelong UMTS exposure in female mice subjected to pretreatment with ENU.
A study of the significance of
cocarcinogenic action and related phenomena.
On the possible carcinogenic and
cocarcinogenic action of overheated fats (review of the literature).
Lutero noted that the effects of cypermethrina photostable synthetic Type II pyrethroid pesticideon test animals include reduced fertility and reproduction rates, carcinogenic and
cocarcinogenic effects through topical route and DNA damage in vital organs like the brain, liver and kidneys.
In fact, experimental evidence has suggested that a fibre-depleted diet may have
cocarcinogenic potential in colorectal cancer, while a high fibre diet may have a protective, anticarcinogenic effect [38].
Indeed HSV has shown
cocarcinogenic activity in combination with chemicals in vivo [162].
Carcinogenic and
cocarcinogenic potential of cypermethrin on mouse skin.
However, there is strong experimental, but as yet unsettled, epidemiologic and molecular evidence to suggest a possible carcinogenic or
cocarcinogenic role of viruses such as SV40, a monkey polyoma virus, in the induction of MM.
Interference by arsenite of the activation of p53 via poly-ADP-ribosylation may be involved in its comutagenic and
cocarcinogenic effects (Yu et al.