[5-8] Many substances can act as primary pollutants, irritants and carcinogenic or cocarcinogenic
Capsaicin also has a cocarcinogenic
effect on TPA-promoted skin carcinogenesis in vivo ; this is mediated through the transient receptor potential vanilloid subfamily number 1 and the tyrosine kinase epidermal growth factor receptor.
Vanillin consumed orally had no effect on ACF; however, when administered through intraperitoneal injection at higher concentration vanillin was cocarcinogenic
, which could well increase ACF density and multiplicity.
The authors concluded that the study showed a cocarcinogenic
effect of lifelong UMTS exposure in female mice subjected to pretreatment with ENU.
A study of the significance of cocarcinogenic
action and related phenomena.
On the possible carcinogenic and cocarcinogenic
action of overheated fats (review of the literature).
Lutero noted that the effects of cypermethrina photostable synthetic Type II pyrethroid pesticideon test animals include reduced fertility and reproduction rates, carcinogenic and cocarcinogenic
effects through topical route and DNA damage in vital organs like the brain, liver and kidneys.
In fact, experimental evidence has suggested that a fibre-depleted diet may have cocarcinogenic
potential in colorectal cancer, while a high fibre diet may have a protective, anticarcinogenic effect .
Indeed HSV has shown cocarcinogenic
activity in combination with chemicals in vivo .
Carcinogenic and cocarcinogenic
potential of cypermethrin on mouse skin.
However, there is strong experimental, but as yet unsettled, epidemiologic and molecular evidence to suggest a possible carcinogenic or cocarcinogenic
role of viruses such as SV40, a monkey polyoma virus, in the induction of MM.
Interference by arsenite of the activation of p53 via poly-ADP-ribosylation may be involved in its comutagenic and cocarcinogenic
effects (Yu et al.