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An organic substance that reversibly combines with a specific protein, the apoenzyme, and with a substrate to form an active enzyme system.

co′en·zy·mat′ic (-zə-măt′ĭk) adj.
co·en′zy·mat′i·cal·ly adv.


of or relating to coenzymes
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A high number of recent data showed that thiamine actions are not limited only to a coenzymatic role, but even its noncoenzymatic roles are relevant, particularly in neuroprotection and, then, in neurodegenerative diseases [10, 11].
The theory that Cbl may impact on the NOS indirectly, through the contribution of its two known mammalian coenzymatic functions to NOS substrate and cofactor assembly and, indeed, to assembly of the NOS protein itself [39], may further explain our findings, including the Cbl-promoted high NOS protein (Figure 10 scheme).
Pante-thine is the coenzymatic form of vitamin B5 (panto-thenic acid) and cysteamine.