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1. One of two or more contributing factors.
2. A substance, such as a metallic ion or coenzyme, that must be associated with an enzyme for the enzyme to function.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.


1. (Mathematics) maths a number associated with an element in a square matrix, equal to the determinant of the matrix formed by removing the row and column in which the element appears from the given determinant. See minor
2. (Biochemistry) biochem a nonprotein substance that forms a complex with certain enzymes and is essential for their activity. It may be a metal ion or a coenzyme
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014


(ˈkoʊˌfæk tər)

1. a contributing factor.
2. any of various organic or inorganic substances necessary to the function of an enzyme.
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.cofactor - a substance (as a coenzyme) that must join with another to produce a given result
chemical compound, compound - (chemistry) a substance formed by chemical union of two or more elements or ingredients in definite proportion by weight
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
References in periodicals archive ?
Vitamin K is a cofactor in a number of biochemical pathways, most importantly activating blood clotting factors and osteocalcin, the protein responsible for organizing calcium deposition in bones.
Their topics include organizing bioactive compound discovery in target gene families, cofactor chemogenomics, chemogenomics with protein secondary-structure mimetics, database systems for knowledge-based discovery, off-target networks derived from ligand set similarity, the chemogenomic analysis of safety profiling data, network and pathway analysis of compound-protein interactions, the flexible pocketome engine for structural chemogenomics, analyzing protein family landscapes with structure-based chemogenomics, and hypothesis-driven screening.
The possible exceptions, histidinal and histinidol, may have resulted from components of a vestigial cofactor pathway.
The biotechnology company's cancer-drug candidate CoFactor failed to meet its goal in a midstage study.
Other experiments will utilize aldo-keto reductases that utilize NADPH as a cofactor.
today announced the initiation of a Phase II clinical trial using CoFactor in the treatment of refractory metastatic breast cancer.
EBV is at least a contributory cofactor in endemic Burkitt lymphoma, but the virus is detected in <20% of sporadic cases in the United States.
ATLANTA -- Herpes simplex virus-2 does not appear to be a cofactor of human papillomavirus in the development of cervical cancer, Dr.
Because folate is an important cofactor in one-carbon metabolism, individuals who are exposed to folic acid fortification and consume a diet high in soy may experience an additive or even synergistic effect on DNA methylation.
Rubber yield is a function of the availability of substrate and cofactor, the rate of reaction, and the number of reactions occurring at any one time.
Normal levels of copper will help decrease inflammation and is a cofactor in collagen synthesis.
Catalytic activity of NOS requires the substrate Larginine, the cofactor is 6R-5,6,7,8-tetrahydro-biopterin (BH4), calcium/calmodulin complex, oxygen and reductants.