Vitamin K is a cofactor
in a number of biochemical pathways, most importantly activating blood clotting factors and osteocalcin, the protein responsible for organizing calcium deposition in bones.
Their topics include organizing bioactive compound discovery in target gene families, cofactor
chemogenomics, chemogenomics with protein secondary-structure mimetics, database systems for knowledge-based discovery, off-target networks derived from ligand set similarity, the chemogenomic analysis of safety profiling data, network and pathway analysis of compound-protein interactions, the flexible pocketome engine for structural chemogenomics, analyzing protein family landscapes with structure-based chemogenomics, and hypothesis-driven screening.
The possible exceptions, histidinal and histinidol, may have resulted from components of a vestigial cofactor
The biotechnology company's cancer-drug candidate CoFactor
failed to meet its goal in a midstage study.
Other experiments will utilize aldo-keto reductases that utilize NADPH as a cofactor
today announced the initiation of a Phase II clinical trial using CoFactor
in the treatment of refractory metastatic breast cancer.
EBV is at least a contributory cofactor
in endemic Burkitt lymphoma, but the virus is detected in <20% of sporadic cases in the United States.
ATLANTA -- Herpes simplex virus-2 does not appear to be a cofactor
of human papillomavirus in the development of cervical cancer, Dr.
Because folate is an important cofactor
in one-carbon metabolism, individuals who are exposed to folic acid fortification and consume a diet high in soy may experience an additive or even synergistic effect on DNA methylation.
Rubber yield is a function of the availability of substrate and cofactor
, the rate of reaction, and the number of reactions occurring at any one time.
Normal levels of copper will help decrease inflammation and is a cofactor
in collagen synthesis.
Catalytic activity of NOS requires the substrate Larginine, the cofactor
is 6R-5,6,7,8-tetrahydro-biopterin (BH4), calcium/calmodulin complex, oxygen and reductants.