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1. One of two or more contributing factors.
2. A substance, such as a metallic ion or coenzyme, that must be associated with an enzyme for the enzyme to function.


1. (Mathematics) maths a number associated with an element in a square matrix, equal to the determinant of the matrix formed by removing the row and column in which the element appears from the given determinant. See minor
2. (Biochemistry) biochem a nonprotein substance that forms a complex with certain enzymes and is essential for their activity. It may be a metal ion or a coenzyme


(ˈkoʊˌfæk tər)

1. a contributing factor.
2. any of various organic or inorganic substances necessary to the function of an enzyme.
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.cofactor - a substance (as a coenzyme) that must join with another to produce a given result
chemical compound, compound - (chemistry) a substance formed by chemical union of two or more elements or ingredients in definite proportion by weight
References in periodicals archive ?
Ryan points to the enzyme's use of an iron-based cofactor to sustain a reaction, similar to what was observed from anammox bacteria.
US-based RNA sequencing and expression analysis platform Cofactor Genomics has raised USD 18m in a financing led by Menlo Ventures with major participation from existing investor Data Collective (DCVC) and new investor Ascension Ventures, and participation from existing and new investors iSelect, Y Combinator, Wilson Sonsini Goodrich and Rosati, and Stanford, the company said.
Hydrogen borrowing requires mutually compatible cofactors shared by two enzymes and in some cases will require redesign of cofactor specificity.
12] is a required cofactor for methionine synthase, while folic acid is a required cofactor for 5, 10-methylenetetrahydrofolate reductase.
com, an on line destination for automotive consumers, CareerBuilder, a human capital solutions and other powerful brands such as G/O Digital and Cofactor.
From kinetic and spectroscopic analysis of FeMo cofactor Thomas Spatzal et al.
US-based RNA products and applications specialist Cofactor Genomics has acquired US-based Narus Biotechnologies, a biomarker development company focused on creating RNA diagnostic tests for neurological diseases, the Cofactor said.
Comment: Biotin is a cofactor for acetyl-CoA carboxylase, a potentially rate-limiting enzyme in myelin synthesis.
The reagents are fluorescent detection analytes that competitively bind to a key cofactor binding site of enzymes that catalyze methylation of histones, DNA, and RNA.
In this case, the initial VWD testing panel identified significantly decreased plasma von Willebrand factor ristocetin cofactor activity (VWF:RCo), with a discordantly low ratio of VWF:RCo to von Willebrand factor antigen level (VWF:Ag) and normal coagulation factor VIII activity, suggesting types 2A, 2B, or 2M VWD (or acquired von Willebrand syndrome).
The amount of cofactor needed to achieve saturation is larger for an inefficient enzyme than for a normal enzyme.