Also found in: Thesaurus, Medical, Legal, Financial, Encyclopedia, Wikipedia.
Related to colony-stimulating factor: Granulocyte colony-stimulating factor, macrophage colony stimulating factor, colony stimulating factor 2
n. Abbr. CSF
1. Any of several cytokines that are produced by a variety of cell types and that stimulate progenitor cells in the bone marrow to produce specific types of blood cells, especially white blood cells such as granulocytes. In vitro, these cytokines stimulate the formation of colonies of cells from a single cell.
2. Any of various recombinant forms of one of these cytokines, such as filgrastim, used as a drug.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.
(Biochemistry) immunol any of a number of substances, secreted by the bone marrow, that cause stem cells to proliferate and differentiate, forming colonies of specific blood cells. Synthetic forms are being tested for their ability to reduce the toxic effects of chemotherapy. Abbreviation: CSF
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014