colony-stimulating factor


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colony-stimulating factor

n. Abbr. CSF
1. Any of several cytokines that are produced by a variety of cell types and that stimulate progenitor cells in the bone marrow to produce specific types of blood cells, especially white blood cells such as granulocytes. In vitro, these cytokines stimulate the formation of colonies of cells from a single cell.
2. Any of various recombinant forms of one of these cytokines, such as filgrastim, used as a drug.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.

colony-stimulating factor

n
(Biochemistry) immunol any of a number of substances, secreted by the bone marrow, that cause stem cells to proliferate and differentiate, forming colonies of specific blood cells. Synthetic forms are being tested for their ability to reduce the toxic effects of chemotherapy. Abbreviation: CSF
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014
References in periodicals archive ?
In the clinical trial, 275 patients were randomized to either placebo with granulocyte-macrophage colony-stimulating factor or NPS with GM-CSF, while all received trastuzumab every 3 weeks for one year.
After obtaining the approval of the bioethics committee of the Medical University of Bialystok for therapy with granulocyte colony-stimulating factor (G-CSF), we administered G-CSF in this patient.
Topical granulocyte-macrophage colony-stimulating factor (GM-CSF) may have a desirable effect on macrophages.
IMPALA is a pivotal Phase 3 clinical study evaluating Molgradex, an inhaled formulation of recombinant human granulocyte-macrophage colony-stimulating factor, for the treatment of autoimmune pulmonary alveolar proteinosis, or aPAP.
Each injection was accompanied by a dose of incomplete Freund's adjuvant and a 75-[micro]g dose of granulocyte-macrophage colony-stimulating factor.
ROLONTIS is a novel, long-acting granulocyte colony-stimulating factor being studied as a treatment for neutropenia in patients undergoing treatment with myelosuppressive cytotoxic chemotherapy.
F-627 is a recombinant human granulocyte colony-stimulating factor (rhG-CSF) dimer with a best-in-class potential to manage CIN in cancer patients.
Recombinant human granulocyte-macrophage colony-stimulating factor improved active Crohn's disease in a small study, reported Dr.
Savara announced completion of the target enrollment of 30 patients in OPTIMA, a Phase 2a clinical study evaluating its lead product candidate Molgradex, an inhaled formulation of recombinant human granulocyte-macrophage colony-stimulating factor, or GM-CSF, for the treatment of nontuberculous mycobacterial, or NTM, lung infection.

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