combination therapy


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combination therapy

n.
The simultaneous use of multiple drugs or other agents as part of a treatment regimen against a specific disease to improve effectiveness, prevent the development of drug resistance, and minimize side effects.
References in periodicals archive ?
However, because the clinical evidence is immature, the cost-effectiveness estimates for pembrolizumab combination therapy are very uncertain.
"Ultimately, overall patient satisfaction was achieved more frequently in those subjects who utilized the combination therapy."
The combination therapy that was administered for a fixed duration of 12 months, decreased the risk of disease worsening or death by 65%, in comparison to obinutuzumab plus chlorambucil.
KEYWORDS: Combination therapy, Medical expulsive therapy, Phloroglucinol, Tamsulosin, Ureteral calculi.
Despite the use of MTX monotherapy, many patients tend to have high disease activity and have to rely on either combination therapy employing conventional DMARDs or biologics5,6.
AstraZeneca and Merck will share the development and commercialization costs for Lynparza and selumetinib monotherapy and non-PD-Ll/PD-1 combination therapy opportunities.
Out of 74 male hypertensives, 48 were treated with monotherapy while 26 were on combination therapy. Similarly, out of 38 female hypertensives, 25 were on monotherapy while 13 were on combination therapy (Table 1).
The closed triple combination therapy consists of three medicines: fluticasone furoate, an inhaled corticosteroid (ICS); umeclidinium, a long-acting muscarinic antagonist (LAMA); and vilanterol, a long-acting beta-adrenergic agonist (LABA).
However, if the hemoglobin [A.sub.1c] is 9% or greater, initial combination therapy with metformin plus another drug may achieve an HbAlc target more quickly than sequential therapy, he said.
Combination therapy can be prescribed for initiation of treatment (at entry of patient into the health care system), or as part of an intensification regime.3 Available FDCs offer dual or triple oral therapy in various forms, while free combinations can deliver upto four drugs at a time.
Comparisons were made between combination therapy, placebo plus ChEI, and placebo only.
During titration, guanfacine monotherapy lowered children's pulse and blood pressure; dexmethylphenidate increased pulse, blood pressure, and QTc interval; and combination therapy increased diastolic blood pressure alone.