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Related to continuous epitope: Antigenic determinants


A small molecular region of an antigen that binds to a particular antibody or antigen receptor on a T cell; an antigenic determinant. A single antigen can have multiple epitopes.

[epi- + Greek topos, place, spot.]


(Medicine) the site on an antigen at which a specific antibody becomes attached


(ˈɛp ɪˌtoʊp)

a site on an antigen at which an antibody can bind, the molecular arrangement of the site determining the specific combining antibody. Also called antigenic determinant .
[1970–75; epi- + -tope < Greek tópos place; compare topo-]
ThesaurusAntonymsRelated WordsSynonymsLegend:
Noun1.epitope - the site on the surface of an antigen molecule to which an antibody attaches itself
immunology - the branch of medical science that studies the body's immune system
site, situation - physical position in relation to the surroundings; "the sites are determined by highly specific sequences of nucleotides"
antigen - any substance (as a toxin or enzyme) that stimulates an immune response in the body (especially the production of antibodies)
References in periodicals archive ?
Several implications of the epitope analysis we have performed argue against hcTnI being globular, at least in the uncomplexed form that was used for immunization: (a) all 16 anti-hcTnI mAbs recognized a continuous epitope markedly; this contrasts with the observation that most mAbs to globular proteins show a conformation-dependent recognition [12] and, therefore, do not react with short peptides; (b) several helices of hcTnI are antigenic, which means that they are probably exposed to the solvent and not packed together as in globular proteins; and (c) we observed that regions connecting the predicted helices of hcTnI are not antigenic; this is in sharp contrast with the fact that turn regions in globular proteins are generally antigenic.

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