Aldose reductase activity has been implicated as a strong contributing factor to pathogenesis in DbCM, a fatal fibrosis of the heart that occurs in both type 1 and type 2 diabetic patients, which leads to decreased contractility
and decreased heart function, eventually resulting in overt heart failure.
MYK-491, MyoKardia's second product candidate, is designed to increase cardiac output among patients with systolic heart dysfunction by increasing the overall extent of the heart's cardiac contractility
. MyoKardia is currently evaluating MYK-491 in a Phase 1b/2a study in stable heart failure patients.
In particular, we will disturb actin contractility
and the cytokine environment in a controlled manner.
Heart models however, continue to present challenges regarding contractility
According to the company, the Optimizer Smart System is the first and only CCM (Cardiac Contractility
Modulation) device approved by the US FDA to improve six-minute hall walk distance, quality of life and functional status of NYHA Class III heart failure patients, who are not indicated for CRT and have an LVEF ranging from 25% to 45%.
Examinations of fruit fly muscles with this mutation supported the "increased contractility
hypothesis," which proposes that the heart is spending more time in a contracted state than in a relaxed state.
The effects of mitoTEMPO on the gastrointestinal contractility
of the isolated ileal and duodenal segments of adult and aged rats were examined.
of RV results in septal push to left ventricle that further impairs ventricular filling.
LVDP and +dP/[dt.sub.max] were monitored and used as the contractility
A new type of treatment called cardiac contractility
modulation (CCM) appears to improve heart function in heart-failure patients with few other options.
EF is dependent on the myocardial contractility
.  Usually, the left ventricular EF (LV EF) is measured, as the left ventricle is the main chamber that pumps oxygenated blood to supply all parts of the body.
T3 hormones show their effects on heart rate, contractility
, systemic vascular resistance and diastolic function.