corepressor


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Related to corepressor: inducer, coactivator

co·re·pres·sor

 (kō′rĭ-prĕs′ər)
n.
A substance that combines with and activates a genetic repressor, thus preventing gene transcription and inhibiting protein synthesis.

corepressor

(ˌkəʊrɪˈprɛsə)
n
a small molecule that combines with, and activates, a repressor
Translations
corépresseur
References in periodicals archive ?
These SNPs located in or near genes ligand dependent nuclear receptor corepressor like, non-SMC condensin I complex subunit G (NCAPG), leucine aminopeptidase 3, LIM domain binding 2, quinoid dihydropteridine reductase, prominin 1, and transmembrane anterior posterior transformation 1.
The activation causes PPAR-[gamma] forms heterodimer with retinoid X receptors (RXRs) so that corepressor is formed that can inhibit gene expression of TGF-[beta]1 [15].
40 - THERMODYNAMIC AND STRUCTURAL ANALYSIS OF SPEN PARALOG AND ORTHOLOG C-TERMINAL DOMAIN AND NCOR COREPRESSOR COMPLEX.
Sensors and signals: A coactivator / corepressor / epigenetic code for integrating signal-dependent programs of transcriptional response.
Nakamura et al., "MCRIP1, an ERK substrate, mediates ERK-induced gene silencing during epithelial-mesenchymal transition by regulating the corepressor CtBP," Molecular Cell, vol.
Among the target genes are BCL6interacting corepressor (Bcor) and RuvB-like protein 1(Ruvbl1), two chromatin modifiers studied in various chromatin complexes [34-38].
Milbrandt, "NAB2, a corepressor of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli," Molecular and Cellular Biology, vol.
It is a transcriptional corepressor that affects signaling pathways and is also involved in modulating differentiation through inhibition of the Wnt / beta catenin signaling cascade [21].
In the classical signaling pathway, testosterone that diffuses through the cell membrane interacts with AR in the cytoplasm and then translocates to nucleus, binds AREs in gene regulatory regions, and recruits coactivator or corepressor proteins to regulate gene expression [9].
At promoters, DNA methylation generally precludes transcription directly by blocking the binding of transcriptional activators or indirectly through the recruitment of methyl-binding proteins and corepressor complexes containing histone deacetylases (HDACs), which cooperatively facilitate the formation of heterochromatin [19].
This offers greater flexibility in response to diverse ligands, resulting in different receptor conformations and coactivator and/or corepressor recruitment in different tissues [169].