These SNPs located in or near genes ligand dependent nuclear receptor corepressor
like, non-SMC condensin I complex subunit G (NCAPG), leucine aminopeptidase 3, LIM domain binding 2, quinoid dihydropteridine reductase, prominin 1, and transmembrane anterior posterior transformation 1.
(18) Moreover, the nuclear receptor corepressor
is well-known protein in association with the RXR receptors.
The activation causes PPAR-[gamma] forms heterodimer with retinoid X receptors (RXRs) so that corepressor
is formed that can inhibit gene expression of TGF-[beta]1 .
40 - THERMODYNAMIC AND STRUCTURAL ANALYSIS OF SPEN PARALOG AND ORTHOLOG C-TERMINAL DOMAIN AND NCOR COREPRESSOR
Sensors and signals: A coactivator / corepressor
/ epigenetic code for integrating signal-dependent programs of transcriptional response.
Nakamura et al., "MCRIP1, an ERK substrate, mediates ERK-induced gene silencing during epithelial-mesenchymal transition by regulating the corepressor
CtBP," Molecular Cell, vol.
Among the target genes are BCL6interacting corepressor
(Bcor) and RuvB-like protein 1(Ruvbl1), two chromatin modifiers studied in various chromatin complexes [34-38].
Milbrandt, "NAB2, a corepressor
of NGFI-A (Egr-1) and Krox20, is induced by proliferative and differentiative stimuli," Molecular and Cellular Biology, vol.
It is a transcriptional corepressor
that affects signaling pathways and is also involved in modulating differentiation through inhibition of the Wnt / beta catenin signaling cascade .
In the classical signaling pathway, testosterone that diffuses through the cell membrane interacts with AR in the cytoplasm and then translocates to nucleus, binds AREs in gene regulatory regions, and recruits coactivator or corepressor
proteins to regulate gene expression .
At promoters, DNA methylation generally precludes transcription directly by blocking the binding of transcriptional activators or indirectly through the recruitment of methyl-binding proteins and corepressor
complexes containing histone deacetylases (HDACs), which cooperatively facilitate the formation of heterochromatin .
This offers greater flexibility in response to diverse ligands, resulting in different receptor conformations and coactivator and/or corepressor
recruitment in different tissues .