Also found in: Thesaurus, Medical, Encyclopedia, Wikipedia.


The process by which squamous epithelial cells in vertebrate animals develop into tough protective layers or structures such as hair, hooves, and the outer layer of skin; the final stage of keratinization.

[Latin cornū, horn; see ker- in Indo-European roots + -fication.]


the process of producing a horn or horny substance


(ˌkɔr nə fɪˈkeɪ ʃən)

the formation of a horny layer of skin, or horny skin structures, as hair, nails, or scales, from squamous epithelial cells.
[1835–45; corn2 + -i- + -fication]


organic change into a hornlike form.
See also: Bones
Mentioned in ?
References in periodicals archive ?
Chemical concentration was lower for GE than SE due to the lack of cornification (stratum corneum) in GE.
Hence, photosensitive substances in wart tissues were hardly excited, augmenting the recurrence rate by preventing cells from necrosis or skin damages from pigmentation and cornification.
Sixteen suggest various reasons for the rarity; less vaginal secretion and free drainage was mentioned nine times; cornification of the cervical epithelium resists the development of carcinoma was suggested nine times; the lessened area of infection in a prolapsed cervix may safeguard the patient from developing carcinoma was spoken of four times.
After clearing the vaginal/uterine infection, bithces were advised for mating after confirmation of > 60 percent cornification in vaginal cytology.
The degree of cornification was highest at the gingiva followed by dorsum of the tongue, cheek & the ventral surface of the tongue.
In cultures of normal human epidermal keratinocytes, treatment with TCDD increased the expression of many genes involved in cornification and EPB formation (Kennedy et al.
2 Through its action on steroid-thyroid hormone superfamily nuclear receptors it interferes with epidermal cell proliferation differentiation and cornification hence its use in epidermal hyperproliferative conditions.
Acute effects of ovariectomy on pituitary LH, uterine weight, and vaginal cornification.
Psoriasis vulgaris, chronic (atopic) eczema, hand and foot eczema, skin cornification disorders (ichthyosis), infectious skin diseases, and itching (pruritus and prurigo) are therefore covered as the main dermatological areas of application for the iodine-sulfur springs.
25 times that of 1713-estradiol by a vaginal cornification assay Uones et al.
1997) found that immature mice showed early vaginal opening, premature cornification of vagina and increased uterine weight when treated with benzene extract of Hibiscus rosa sinensis flowers @ 125 and 250 mg/kg body weight intraperitoneally.