reported that in A0T/H20/toluene systems, the acrylamide acts as a cosurfactant
during the polymerization and is mostly located at the w/o interface rather than inside the micelles.
Nanoemulsions are thermodynamically stable, transparent nano-dispersions that are smaller than 100 nm in droplet size, stabilized by an interfacial film formed by surfactant and cosurfactant
An aqueous emulsifier mix containing 3.4 ml Tween 80 (surfactant), 1.1 ml n-butanol (cosurfactant
), and 2.1 ml distilled water was stirred at a speed of 300 rpm and at a temperature of 70[degrees]C on a hot plate magnetic stirrer.
Briefly, mixtures of cyclohexane (75 ml), Triton X-100 (17.7 ml), and n-hexanol (18 ml) as oil, surfactant, and cosurfactant
phases, respectively, were mixed with 4.8 ml aliquots of Rubpy dye solution (20 mM in deionized water).
The major technique for enhancing bio-availability is SEDDS, which uses lipophilic, pre-concentrated solutions of the active pharmaceutical ingredient and excipients (a liquid carrier, a surfactant and a cosurfactant
To find out the suitable components for dexibuprofen microemulsion, the solubility of dexibuprofen in oil (ethyl oleate), surfactants (Tween 40,60, and 80 and triethanolamine), and cosurfactant
(PG, PVA, PEG 400, and ethanol) was determined through method reported by Roni and Jalil .
Curcumin water solubility was also increased successfully using a microemulsion vehicle containing a surfactant, oil, and cosurfactant
and this increase in water solubility translated in an about 22 times higher bioavailability of curcumin in rats .
These are stabilized by an interfacial film of surfactant and cosurfactant
Stability of WCO emulsions Range of WCO Emulsion Proportions without Co-Surfactant WCO (%) Water (%) Surfactant (%) Stability 92 4 4 4 hrs 95 3 2 2 hrs 90 5 5 6 hrs 80 13 7 3 hrs 84 10 6 5 hrs Range of WCO Emulsion with Co-Surfactant (Ethanol) WCO (%) Water (%) Surfactant to Cosurfactant
%) Stability 50 20 15 15 2 days 75 9 8 8 8 days 65 15 10 10 3 days 80 10 5 5 20 days 92 4 2 2 5 days
Alcohols could change the osmotic pressure of the latex particle surface as they work as cosurfactant
Kinetics and effect of surfactant and cosurfactant
on miniemulsion polymerization of acrylate monomers--Hongqiang Li, Xiaokang Ren, Xuejun Lai, and Xingrong Zeng