Inhibition With Dapagliflozin in Type 2 Diabetes Diabetes Care.
A novel missense mutation in SLC34A3 that causes hereditary hypophosphatemic rickets with hypercalciuria in humans identifies threonine 137 as an important determinant of sodium-phosphate cotransport
In one study, it was found that those osteoporotic patients who took thiazide diuretic had 0.87 times the risk of having fractures compared to those who did not take the drug.2 Proposed mechanism through which Thiazide diuretic decreases the risk of having fracture is by not only increasing calcium reabsorption by the kidney but also by inhibiting sodium-chloride cotransport
in osteoblast thus increasing calcium levels in the bones.3
In crustaceans, the salt intake from the gut to the hemolymph is explained by various mechanisms such as the simultaneous co-transport of ions and the cotransport
of sodium with amino acids and glucose in M.
proposed that in sickle cells, an abnormal activation of potassium chloride ([K.sup.+] [Cl.sup.-]) cotransport
system was involved in cell potassium ([K.sup.+]) loss and dehydration.
Patients with altered renal function produce less erythropoietin, with a consequent reduction of erythropoiesis, which, in a not yet fully understood way, reduces the cotransport
of iron to the CNS and medulla .
Meier, "Functional expression cloning and characterization of the hepatocyte Na+/bile acid cotransport
system," Proceedings of the National Acadamy of Sciences of the United States of America, vol.
Fiedorek, "Sodium-glucose cotransport
inhibition with dapagliflozin in type 2 diabetes," Diabetes Care, vol.
Using the electrochemical gradient of [Na.sup.+] and through cations channels, magnesium enters cells via [Mg.sup.2+]/anion cotransport
. Eight cation channels have been identified including transient receptor potential melastatin cation channels 6 and 7 (TRPM6, TRPM7), members 1 and 2 (SLC41A1, SLC41A2) channels, ancient conserved domain protein 2 (ACDP2), the mitochondrial RNA splicing 2 protein (Mrs2p), magnesium transporter 1 (MagT1), the human solute carrier family 41, and paracellin-1 .
The [Na.sup.+]/K/Cl cotransport
system concentrates radioactive iodine in the salivary gland and makes the salivary glands prone to dysfunction [3, 7].
in Ehrlich cells: regulation by protein phosphatases and kinases.