Mortality of two groups of women who manufactured gas masks from chrysotile and crocidolite
asbestos: a 40-year follow-up.
Importantly, the exposure effects studied were the consequence of pure crocidolite
Rodlike amphibolyte fibers, namely the crocidolite
types, contribute to the pathogenesis of the majority of these tumors.
OBJECTIVES: We sought to examine the importance of XRCC1 in protection against genotoxic effects of crocidolite
and Libby amphibole asbestos.
Epidemiological evidence has increasingly shown an association of all forms of asbestos (chrysotile, crocidolite
, amosite, tremolite, actinolite, and anthophyllite) with an increased risk of lung cancer and mesothelioma.
A naturally occurring silicate mineral, asbestos is classified in two forms: amphibole (which includes amosite, crocidolite
, tremolite, anthophyllite, and actinolite) and serpentine (also known as chrysotile).
Amphibole minerals include five asbestos species: amosite, crocidolite
, tremolite, anthophyllite, and actinolite.
Asbestos use peaked during a construction boom in the early 1960s and subsequently declined by > 90% following a ban on the sale and import of crocidolite
and amosite asbestos in 1996, whereas mesothelioma diagnoses in men increased from a single case in 1972-1976 to 63 cases in 2002-2006 (corresponding to crude incidence rates of 0.
Amphiboles, such as crocidolite
and amosite, were generally believed to be more potent than was chrysotile in inducing mesothelioma (Berman and Crump 2008; Hodgson and Darnton 2000).
Both chrysotile and crocidolite
were used throughout the entire period of activity.
1998) were the first to estimate the quantitative exposure-response relationship between MM and environmental asbestos exposure among residents living near a crocidolite
mine in Wittenoom, Australia.
2 in the omenta have been reported in Big Blue lacI transgenic rats injected with crocidolite
(Unfried et al.