occurs in patients with Chagas disease, but some cross-reactions
are found in patients with glandular tuberculosis or lepromatous leprosy (4).
In this case, the bias caused by the pronounced cross-reaction
of the acylglucuronide in the immunoassay apparently did not compromise the predictive power of the test.
However, attempts to definitively ascribe this increase to PSA were not successful either by immunohistochemistry with PSA monoclonal antibodies (1, 2) or by amplification of PSA by reverse transcription-PCR (RTPCR) (3), suggesting cross-reaction
with a PSA-like protein.
These data suggest that to use hCG[beta]cf as a cancer marker, an assay of very high specificity for this molecule is required because of possible cross-reaction
Subsequent studies demonstrated that much of this immunoreactive [beta]-core could be attributed to cross-reaction
with a metabolite of LH, which we termed [beta]-LH-core and which was almost certainly produced by the same degradation pathways that led to hCG[beta]cf (19).
In keeping with this possibility, a higher sCRP value (66 vs 46 mg/L) was found with the Turbitimer device, using only 11-fold diluted pooled serum A (Table 1), and the level of the cross-reaction
fell from 100% to 47% when the same sample was prediluted fourfold.
Sixteen histamine analogs and other amines including spermidine and spermine were tested for cross-reaction
in the assay system.
Since substantial serologic cross-reaction
occurs between R.
We have previously shown that the major cross-reaction
due to the B7 antigen can effectively be suppressed by an anti-B7 antiserum .
targets contained mutated sequences of the wild-type targets and vice versa.
proposed that the artefactual increase of serum testosterone in some direct assays could reflect cross-reaction
with testosterone conjugates in the serum (testosterone conjugates also are water-soluble and nonextractable by organic solvent).
Because both HTNV and its rodent reservoir are absent from the American biotope, HTNV seroreactivity should be considered a cross-reaction
to another related murine antigen; that is to say, the ratborne SEOV.