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(krôs′rĭ-zĭs′təns, krŏs′-)
Tolerance to a usually toxic substance as a result of exposure to a similarly acting substance: Some insects develop cross-resistance to insecticides.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.


1. immunologic resistance to the pathogenic effects of a microorganism due to previous exposure to another species or type having cross-reactive antigens.
2. (of an insect, bacterium, etc.) resistance to the effects of a pesticide, antibiotic, etc., due to previously acquired resistance to a similar substance.
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
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[11] In the presence of inhA mutations, significant cross-resistance between INH and ethionamide has been observed.
Significantly, SMT-571 did not show cross-resistance with any antibiotic currently or previously used to treat gonorrhoea infections.
Eliminating cockroaches through insecticides alone are becoming 'almost impossible' as the household pests are developing cross-resistance from the chemicals, a recent study found.
The landscape for commercialization of novel antibacterial therapies is rapidly evolving, and there remains a large market opportunity for both broad and narrow spectrum agents that target novel pathways without cross-resistance to existing antibiotics.
Dr Nhung cautioned on cross-resistance between new drug Bedaquiline and Clofazamine.
Biocontrol agents such as Bacillus thuringiensis israelensis (Bti) and Bacillus sphaericus (Bs) are proven to be effective for larval control, and are safe to the environment, due to the quick knockdown of pests, no cross-resistance with traditionally used pesticides, and favorable toxicological profile.
However, in the present study the decreased susceptibility to spinosad in the field strains of stored insects may not be linked with the cross-resistance, since a number of insects showing resistance to other insecticides don't show cross-resistance to spinosad owing to the fact of a unique mode of action (Shono and Scott, 2003; Khan et al., 2014, 2015c) as it acts at the GABA receptor and nicotinic acetylcholine receptor sites of the insect nervous system (Salgado, 1998).
monocytogenes cells that encountered heat stress can induce cross-resistance to subsequent treatments with essential oils.
The rapid development of resistance and cross-resistance or co-resistance to other antimicrobial agents and classes are always of concern after the introduction of a new antimicrobial agent into clinical use.
Miltefosine is also a good option in patients who are resistant to pentavalent antimony or exhibit cross-resistance to amphotericin B.6 The terminal half-life of miltefosine is long which ranges between 150 and 200 hours and about four half-lives (25-33 days) are needed to reach more than 90% of the peak levels, thereby a subtherapeutic level of miltefosine may remain for some weeks after a 4 week course.8 This feature might encourage the emergence of resistance but it can be prevented by ensuring good compliance and adequate dosing for adequate duration or by using combination therapies.8