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(krôs′tŏl′ər-əns, krŏs′-)
Tolerance or resistance to an effect or effects of a compound as a result of tolerance previously developed to a pharmacologically similar compound.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.


resistance or low reaction to the effects of a drug, poison, etc., because of tolerance to a pharmacologically similar substance.
Random House Kernerman Webster's College Dictionary, © 2010 K Dictionaries Ltd. Copyright 2005, 1997, 1991 by Random House, Inc. All rights reserved.
References in periodicals archive ?
Seed priming sets in motion activities involved in seed germination, such as respiration, endosperm weakening and seed reserve (starch) degradation, which facilitate the transition of quiescent dry seeds into germinating state and increase the germination potential and imposes abiotic stress to germinating seeds to stimulate stress responses (e.g., activation of ROS scavenging systems and accumulation of stress response proteins), hence inducing cross-tolerance (Li et al., 2013; Chen and Arora 2012).
* Patients receiving rotating opioid medication regimens (and thus are at risk for incomplete cross-tolerance)
The role of calcium and activated oxygens as signals for controlling cross-tolerance, Trends Plant Sci., 5: 241-246
Although the neurobiological mechanism underlying the withdrawal signs decrement as a consequence of voluntary exercise is yet unclear, a possible explanation for this may be related to the development of cross-tolerance phenomenon.
In addition to pure TNF tolerance, several forms of TNF/LPS cross-tolerance have been described [5-7].
Dehydration at a slow rate confers cross-tolerance to cold in larvae of Belgica antarctica (Hayward et al., 2007).
Animal studies also suggest that there is "cross-tolerance" between cannabis and barbiturates, opioids, benzodiazepines, and phenothiazines (Ashton 1999).
Her dissertation entitled The role of nicotinic acetylcholine receptor a4~32 and cz7 in nicotine-ethanol interaction and cross-tolerance: Functional correlation with cerebellar nitric oxide.
In addition, NMDA activity "may mean that it reduces some of the cross-tolerance that we see with patients being converted from another opioid to methadone," she said.
These include cross-tolerance, withdrawal mediation, replacement, alternating addiction cycles, masking, ritualizing, intensification, numbing, disinhibiting and combining.
Because cross-tolerance between methadone and other opioids is incomplete, switching patients from other opioids to methadone is complex, so patients with a tolerance for other opioids can experience a methadone overdose.