(CTX) is the main toxin isolated from Brazilian rattlesnake Crotalus durissus terrificus (C.
(2013) Intraspecies variation in the venom of the rattlesnake Crotalus simus from Mexico: Different expression of crotoxin
results in highly variable toxicity in the venoms of three subspecies.
(6) Cobra venom contains cobratoxin and a-bungarotoxin which act postsynaptically by binding to acetylcholine receptors on the motor end plate while (3-bungarotoxin and crotoxin
present in krait venom act pre-synaptically and prevent release of acetylcholine at the neuromuscular junction resulting in muscle paralysis due to curare like neuromuscular blocking action affecting the muscles of eyes, throat and chest leading to respiratory failure.
alba and three of its constituents, wedelolactone, sitosterol, and stigmasterol, have been investigated for their ability to protect against myotoxicity of crotalid venoms (Bothrops jararaca, Bothrops jararacussu, and Lachesis muta) and purified myotoxins (bothropstoxin, BthTX; bothropasin; and crotoxin
) through quantification in vitro by the release rate of creatine kinase (CK) from rat or mouse extensor digitorum muscles and in vivo by the plasma CK activity in mice.
Whole Crotalus durissus terrificus snake venom induces antinociception in a rat model of cancer pain and crotoxin
inhibits tumor growth.
Domont et al., "Molecular structure and mechanism of action of the crotoxin
inhibitor from Crotalus durissus terrificus serum," European Journal of Biochemistry, vol.
Investigations on the mechanism of action of crotoxin
Crocalbin: a new calcium-binding protein that is also a binding protein for crotoxin
, a neurotoxic phospholipase [A.sub.2].
Edema happens due to direct poison action in muscles, and it has systemic effects on crotoxin
, phospholipase A2, and several other substances that are released in the acute inflammatory phase such as interleukin, bradikinine and histamine (Kini & Evans 1989, Barraviera 1994).
Presynaptic effects of snake venom toxins which have phospholipase A2 activity (beta-bungarotoxin, taipoxin, crotoxin
Furthermore, some neurotoxic sv[PLA.sub.2]s (e.g., notexin and crotoxin
) cause acute skeletal muscle necrosis, adding to systemic toxic effects (i.e., rhabdomyolysis) .
, the phospholipase A2 neurotoxin from the venom of Crotalus durissus terrificus.