Serological tests for hepatitis B, hepatitis C, and human immunodeficiency virus, as well as cryoglobulin
, cold agglutinin, and C3 and C4 were all negative.
Immunological tests showed an antinuclear antibody ratio of 1: 160 with a speckled pattern, anti-SSA/Ro antibody 1: 16, rheumatoid factor 123.9 IU/mL (<15), positive direct Coombs test, and myeloperoxidase (MPO)-ANCA 129 U/mL(<3.5), whereas the tests for cryoglobulin
, anti-hepatitis C, anti-aminoacyl transfer RNA synthetase, anti-double-strand DNA, anti-RNP, anti-Sm, anti-SSB/La, and anti-phospholipid antibodies were all negative.
Our patient also had associated mixed cryoglobulinemia, which was evidenced by a positive cryoglobulin
level with high rheumatoid factor levels.
A serum test for a cryoglobulin
precipitation was negative.
, lupus anticoagulant, and anti-cardiolipin antibodies were all negative.
less than 0.50) CSF, cell count RBCs: 7 Nucleated cells: 21 CSF, differential Neutrophils: 3% Lymphocytes: 81% Monocytes: 16% CSF, VDRL Negative CSF, autoimmune Negative encephalopathy panel CSF, Lactic acid WNL Paraneoplastic Negative panel HIV 1&2 antibody Negative ASO Negative AFP Negative RPR Non-reactive ANA Negative ENA panel Negative VIT b12 WNL Cryoglobulin
Negative Hepatitis B and C Negative ANCA MPO PR3 Negative C3&C4 WNL SPEP (check) No abnormal protein band detected WNL: within normal limit, SPEP: serum protein electrophoresis, ref: reference.
In this article, we aim to present a case with truncal EED and elevated cryoglobulin
count in her blood steadily decreased, and by April of this year it was undetectable.
However in patients lacking cryoglobulin
, demyelinating PN dominate (23,24).
RF, ANA, ANCAs, specific anti- No erosion /2005  filaggrin antibody, and cryoglobulin
were negative Dendle et al.
Anti-double-stranded DNA, anti-extractable nuclear antigen antibody, anti-glomerular basement membrane antibody and cryoglobulin
were not detected.
The diagnosis of antiphospholipid syndrome (anti-cardiolipin and anti-[beta]2-glycoprotein antibodies, lupus anticoagulant), systemic vasculitis (pANCA, cANCA, cryoglobulin
), and systemic connective tissue disease (RF, ANA) were negative.