Histologically, they are composed of 2 predominant cell types (Figures 7 and 8): a histiocytoid cell (round to oval with pink cytoplasm, well-defined nuclei with prominent nuclear grooves, and occasional nucleoli) and a taller columnar or cuboidal cell
Using antibodies against CK5/6 and p63, we were able to selectively label a distinct population of basal layer cells (Figure 5, B), corresponding to both the light and the electron microscopically identified cuboidal cell
layer that is in direct contact with the basal lamina (Figures 3 and 4).
Recently, Chen and Mai (12, 13) provided a new 3D cuboidal cell
model to study the deformation and toughening mechanisms in rubber-modified polymers without a macro-crack using a full, three-dimensional finite element analysis.
They are lined by a single layer of epithelium, which is variously composed of flat, nondescript cells, cells with abundant cytoplasm containing hyaline droplets similar to those seen in hypertrophic proximal tubules, or small cuboidal cells
resembling distal tubular or collecting duct cells (Figure 9, D).
Bile duct adenomas are small (<1 cm), subcapsular, circumscribed, noncystic solitary lesions composed of uniform cuboidal cells
that form tubules.
59) (3) In a small proportion of IPMNs, the papillae are more complex and are lined by cuboidal cells
, often with round nuclei containing a single prominent eccentric nucleolus (Figure 4, C).
41,42) They are histologically identical to what is seen in the female genital tract, being composed of small glandular structures lined by a single layer of cuboidal cells
, usually with dense eosinophilic intraluminal secretory material (Figure 8, E).
The primary tumor in that case was a moderately differentiated breast adenocarcinoma, composed of predominantly cuboidal cells
with scant cytoplasm, growing in ill-formed glands.
The adenomatoid pattern consists of bland flat to cuboidal cells
lining small glandlike structures.
23) Consistent with the immunohistochemistry results, the cuboidal cells
were shown to express cytokeratin, epithelial membrane antigen, surfactant, and TTF-1.