cyclin


Also found in: Medical, Acronyms, Encyclopedia, Wikipedia.

cy·clin

 (sī′klĭn)
n.
Any of a class of proteins that fluctuate in concentration at specific points during the cell cycle and that regulate the cycle by binding to a kinase.

cyclin

(ˈsaɪklɪn)
n
a type of protein in cell nuclei whose concentration changes cyclically throughout the cell cycle
References in periodicals archive ?
IHC staining with CD5, CD20, and cyclin D confirmed the diagnosis of MCL.
Cyclins confer substrate specificity and regulation to Cdk/cyclin complexes.
Among CDK2 inhibitors those with purine-based structures (NU6140 and its derivatives) have shown higher specificity to inhibit CDK2 interaction with cyclin A compared to other interactions (CDK1/cyclin B, CDK4/cyclin D, CDK5/p25, and CDK7/cyclin H) [11, 12].
"In addition to its role in regulating the cell cycle, cyclin D1 induces Dicer and thereby promotes the maturation of miRNA," lead researcher Richard Pestell, M.D., Ph.D., Director of the Kimmel Cancer Center at Thomas Jefferson University and Chair of the Department of Cancer Biology, said.
Dysregulation of cyclin dependent kinase 6 expression in splenic marginal zone lymphoma through chromosome 7q translocations.
The experiments targeted two related proteins, cyclin D1 (http://www.creativebiomart.net/description_6178_19.htm) and cyclin D3, that control cells' growth cycle.
All these results indicate that the cyclin D/Cdk4 complex is an essential regulator in the proliferation of pancreatic [beta]-cells.
Oncologist Harold Burstein, who was not involved in the research, said it was "an important study," having established that the use of cyclin inhibitors "translates into a significant survival benefit for women."
Sodium orthovanadate was reported to stop cell cycles by causing increased cyclin [B.sub.1] expression on HepG2, Sk-Hep-1 and Hep3B liver carcinoma cells relative to dose (14).
Western blot assay was performed to further confirm these results by analysis of cell cycle-related proteins (PCNA, Cyclin A, Cyclin E1, CDK2, Cyclin D1, and CDK4).
The expressions of cyclin D1 and Bcl-xL were detected both at the mRNA level by real-time reverse transcription-polymerase chain reaction (RT-PCR) and at the protein level by Western blotting.
Spermine ingestion significantly increased the gene expressions of cyclin A2 (Group SP-3 d vs Group Con-3 d; Group SP-6 d vs Group Con-6 d; Group SP-9 d vs Group Con-9 d) but markedly decreased mRNA expressions of p21 (Group SP-6 d vs Group Con-6 d; Group SP-9 d vs Group Con-9 d), cyclin D3 (Group SP-6 d vs Group Con-6 d), and cyclin E2 (Group SP-6 d vs Group Con-6 d; p<0.05).