In addition, PC1 was negatively attributed to oxidized form of nicotinamide adenine dinucleotide (NAD+), F-1,6-dP, glycerol 3-phosphate, citric acid, malic acid, cytidine
triphosphate, GTP, and uridine diphosphate (UDP)-linked compounds, indicating that these compounds were abundant in the muscle at slaughter but later decreased.
C282Y mutation which is caused by substitution of tyrosine for cysteine at position 282 due to the substitution of adenosine for guanosine at nucleic acid position 845 (845G>A) and H63D mutation due to substitution of aspartate for histidine at position 63 of amino acid due to the substitution of guanosine for cytidine
at nucleic position 187 (187C>G)6.
(7) APOBEC is a member of the evolutionary conserved family of cytidine
deaminases that are involved in genomic clearance of foreign DNA.
NCC, N-cyclopropyl-4'-azido-2'-deoxy-2'-fluoro-[beta]-D-cytidine, is a novel fluorinated cytidine
ApoGen is initially focusing its drug development efforts on an antiviral component of the human innate immune system, the Apobec cytidine
deaminases, which have been implicated as a prominent source of mutations in cancers.
Lymphotoxin-[beta] receptor signalling has been shown to activate upregulation of cytidine
The current study reveals that viperin catalyzes the conversion of a nucleotide called CTP (cytidine
triphosphate) into a structurally similar compound, or analog: the nucleotide ddhCTP--a previously undescribed molecule that sabotages viral replication.
EPI01 is a novel, orally available, disease-modifying therapy that consists of a fixed-dose formulation of a DNA methyl-transferase enzyme 1 and cytidine
deaminase inhibitor, decitabine and tetrahydrouridine.
This cell line was cultured in C[O.sub.2] (5%) incubator at 37[degrees]C in [alpha]-minimal essential medium ([alpha]-MEM; Invitrogen Co., Ltd., Carlsbad, CA) supplemented with 10% fetal bovine serum, 10 [micro]g each of adenosine, guanosine, cytidine
, and thymidine per milliliter of medium, penicillin G (100 [micro]g [mL.sup.-1]), and streptomycin (100 [micro]g [mL.sup.-1]) as described previously (Oda et al.
Uremic Toxins with Similarities Purine Derivatives: Cytidine
, hypoxanthine, xanthine, uric acid Pyrimidine Derivatives:_Thymine, orotic acid, orotidine, uridine Methyl amine Derivatives:_Methylamine, dimethylamine, trimethylamine Indole Derivatives: Kynurenine, indole-3-acetate, kynurenic acid, melatonin, indoxyl sulfate, quinolinic acid.
Blood was collected in tubes containing 0.75 mg of tetrahydrouridine, a cytidine
deaminase inhibitor, to prevent ex vivo metabolism of gemcitabine.