When a cytologic specimen
demonstrates prominent longitudinal nuclear grooving, a wide range of pathologic lesions should be considered, such as dermatopathic lymphadenopathy.
(2) Granulocytic sarcoma occurs in 3-7% cases of AML and it can present before, during or even after the diagnosis of AML (7) Granulocytic sarcoma may present as a serous effusion and can be diagnosed on a cytologic specimen
Sampling error is reduced, since all the cells are transferred into solution, in contrast with the conventional Pap test (CPT), in which only 20% of the cells are actually transferred to the glass slide. The cytologic specimen
in solution is then sent to the laboratory where most of the debris, leukocytes, and erythrocytes are filtered from the specimen and a thin layer Pap test is prepared using a special processor.
Sputum is the most commonly obtained cytologic specimen
in the initial workup of bacterial pneumonia.
The purposes of this study were (1) to determine the efficacy of a second-generation (HC II) HPV DNA test to detect carcinogenic HPV from residual cells of a liquid-based cervical cytologic specimen
, and (2) to compare the performance of the HC II test with the standard HCT HPV test from a direct cervical swab sampling to detect cervical intraepithelial neoplasia (CIN) in women with Pap smear reports of ASCUS and LSIL.
FISH can be performed on an FFPE tissue or cytologic specimen
. Its testing requires a minimum of 50 to 100 tumor cells and, thus, can be mostly implemented in both material types.
However, it demands that health-care professionals perform cervical screening in a thoughtful and conscientious way so that the cytologic specimen
contains cells from the cervical areas most often involved in disease states.
To assess the extent to which differences in cytologic specimen
types and processing steps influence IHC test results, laboratories should test a selected set of commonly ordered markers (eg, keratin, CD45, S100, ER) in a set of cytologic specimen
types used for IHC staining.
Increasing acceptance of molecular tests into cytopathologic practice is also highlighted by a recent recommendation from the International Mesothelioma Interest Group to conduct p16 (by FISH) and BAP1 (by immunohistochemistry) staining in cytologic specimens
suspicious for mesothelioma.
Because of potential differences in the handling and processing of cytologic preparations, appropriate evaluation of HER2 staining of cytologic specimens
before testing and reporting patient sample is recommended.