Variations in lethal toxin and cholesterol-dependent cytolysin
production correspond to differences in cytotoxicity among strains of Clostridium sordellii.
faecium isolates are characterized by a high frequency of genes encoding putative virulence factors, such as collagen adhesin (acm gene), enterococcal surface protein (esp gene), hyaluronidase (hyl gene), gelatinase (gelE gene), endocarditis antigen (efa gene), and cytolysin
(cyl operon) .
The three dimensional structure of Perfringolysin (PDB ID 1PFO) was selected as a template because it is the thiol-activated cytolysin
whose structure showed better homology with the target sequence (PLY).
Superbugs No of Antibiotic resistance genes carrying by Plasmids the plasmids Enterococcus 95 Tetracycline, Streptothricin, Vancomycin, Erythromycin, Cytolysin
, Chloramphenicol, florfenicol, Tigecycline, Daptomycin, Kanamycin, Streptomycin and Teicoplanin.
Molecular biology of teh pore-forming cytolysin
from Staphylococcus aureus, a and g-hemolysins and leukocidin.
plays an important role in processes such as escape from the immune response, intracellular multiplication and cellular spread, within eukaryotic cells.
Two-component regulator of enterococcus faecalis cytolysin
responds to quorum-sensing autoinduction.
faecium, respectively), enterococcal surface protein (esp for both species), endocarditis-specific antigen A (efaA for both species), collagen-binding proteins (ace/acm); invasins (extracellular metalloendopeptidase also called gelatinase--gelE for both species, hyaluronidase--hyl for both species); cytotoxines (activation of cytolysin
Cytotoxicity with target DNA breakdown by rat basophilic leukemia cells expressing both cytolysin
and granzyme A.
The extracellular cytolysin
of Vibrio vulnificus: inactivation and relationship to virulence in mice.
Moreover, it possesses lytic enzymes, cytolysin
, aggregation substance, pheromones, and lipoteichoic acid (31).
Structure, Function, and Biology of the Enterococcus faecalis Cytolysin