However, these subtypes share common histopathological changes, characterized by neuronal loss, gliosis and the presence of glial cytoplasmic inclusions
(GCI) with a-synuclein.
synuclein in oligodendrocytes, where it forms glial cytoplasmic inclusions
killing neurons and glial cells.
A number of cytoplasmic inclusions
are frequently found, including lipid droplets and lysosomes in the Leydig cells (Fig.
Negri bodies are cytoplasmic inclusions
in neurons that are composed of rabies virus proteins and RNA.
On light microscopy, a good morphologic method to demonstrate Fabry deposits is to use tissues fixed in glutaraldehyde, embedded in Epon, and stained with toluidine blue dye, which yields dark blue cytoplasmic inclusions
in glomeruli, tubules, and arteries (Figure 2, A through D).
The cells are usually bland with round nuclei, often with intranuclear cytoplasmic inclusions
However, Papp and Lantos described high densities of glial cytoplasmic inclusions
in the supplementary and primary motor cortical areas and subjacent white matter and moderate densities of glial cytoplasmic inclusions
in the premotor area, cingulate motor area, and corpus callosum in MSA .
have also been seen in infected cells, though less distinct and smaller, often measuring only 1-3 microns but more readily apparent with special stains such as periodic acid-schiff (PAS) and gomori-methenamine silver (GMS).
Chronic lymphocytic leukemia with IgM lambda and IgG lambda cytoplasmic inclusions
The characteristic cytologic features of conventional melanoma are: high cell-yield, predominant epithelioid/plasmacytoid cells with eccentrically placed nuclei and a dissociated pattern, abundant cytoplasm, cytoplasmic melanin pigments, prominent anisokaryosis, macronucleoli, intra-nuclear cytoplasmic inclusions
, and variable numbers of bi- and multinucleated cells.
The intranuclear CMV inclusions were defined by central, dark-purple bodies that were separated from the surrounding chromatin by a clear halo; the cytoplasmic inclusions
appear as coarse basophilic granules.
They were highly pleomorphic and showed brisk mitoses with some atypical ones (Figure 3a), intranuclear cytoplasmic inclusions
(Figure 3b) and multiple tumour giant cells (Figure 3c).