Vinorelbine softgel is another prime example of a complex oral oncology product successfully developed by Lotus pharmaceuticals with multiple complexities: Cytotoxic drug
, bioequivalence study in cancer patients, softgel capabilities, high potency containment manufacturing, first to market.
Biopharmaceutical company EnGeneIC Limited said on Thursday that it has dosed the first four patients under its Phase 1/2a study of tumor-targeting, immunogenic EDVs to deliver a cytotoxic drug
payload directly to tumors of patients who have exhausted curative treatment options.
Miltefosine was the most cytotoxic drug
with an IC50 of 72.26 in PBLs and a consistently higher % inhibition through all the four studied concentrations.
The PDEA said the government has seized a total of P25.19 billion worth of drugs, cytotoxic drug
cyclopentenyl cytosine (CPEC), and laboratory equipment in the past three years.
Janssen will examine applications of modeling and simulation in order to overcome some of these challenges, such as the preclinical to clinical translation; the cytotoxic drug
molecules creating the bystander effect.
ADCs are composed of an antibody linked to a cytotoxic drug
. The antibody is thought to specifically target and deliver the cytotoxic drug
to the cancer cells.
Thus, the term targeted drug delivery should give its place to navigated drug delivery since it is not only the cytotoxic drug
that targets a specific cellular location but rather a vehicle that navigates the course of the loaded drug to the appropriate site of action.
For this reason, an important trend in the development of new chemotherapeutics is to "arm" the antibodies, for example by coupling them to a cytotoxic drug
, in order to increase their efficacy.The ETHZ researchers under the supervision of Prof.
Prakesh et al.,  in a study on the tenth and twelfth days of pregnancy (organogenic period) on mice have shown that cytotoxic drug
Cyclophosphamide had a significant inhibitory effect on choroid plexus epithelial cells and induces apoptosis in the mouse brain cells .
This is a major milestone for Oasmia, since Paccal Vet is the first parenteral cytotoxic drug
being examined to treat malignant skin cancer in dogs, the company said.
A 1996 study published in the Archives of Environmental Health found that the cytotoxic drug
methotrexate was present in urine samples of nurses who'd been caring for chemotherapy patients.
arjuna against all tested cancer cell lines was arjunic acid, however it was five times less cytotoxic than the cytotoxic drug
vinblastine on cancerous liver cells.