cytotoxic drugs


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cytotoxic drugs

Used to destroy cells, mainly in cancer chemotherapy.
Dictionary of Unfamiliar Words by Diagram Group Copyright © 2008 by Diagram Visual Information Limited
References in periodicals archive ?
It is only recently that ADC's true potentials were fully tapped, thanks to the significant advances in linker engineering, conjugation technologies and continuous development of highly potent cytotoxic drugs.
Antibody Fragment-Drug Conjugates (FDCs, also called immuno-conjugates) combine the pharmacological potency of highly cytotoxic drugs with the high specificity of an antibody against tumour-associated targets.
Based on drug types, global anticancer drugs market is segmented into cytotoxic drugs, targeted drugs, and hormonal drugs.
DNA damage and subsequent induction of apoptosis is the primary mechanism of cytotoxic drugs like antimetabolites and alkylating agents (Rixe and Fojo, 2007).
HCWH said health care waste and byproducts could lead to sharps-inflicted injuries; toxic exposure to pharmaceutical products, such as antibiotics and cytotoxic drugs released into the surrounding environment, and to substances such as mercury or dioxins, during the handling or burning of health care waste.
ADCs are highly potent biopharmaceutical drugs that link complex biological molecules like mAbs with cytotoxic drugs. ADCs have emerged as a promising class of anti-cancer therapeutics due to their high specificity in delivering cytotoxic/ HPAPI drugs to target cells while significantly reducing the side-effects compared to chemotherapies.
Adjuvant treatment options include radiotherapy; a wait-and-see policy; and administration of tamoxifen, non-steroidal antiinflammatory drugs (NSAIDs), and cytotoxic drugs. Hormone therapy may have a significant role, considering the possible hormonal etiopathogenesis of the condition.
The committees would ensure disposal of mercury waste from broken clinical equipment and spillage and cadmium waste from discarded batteries, medical supplies, hospital, clinics, laboratories and veterinary facilities, waste blood, tissue, organs of human and animal bodies in addition to cytotoxic drugs, vomitus feces, syringes, vials, pharmaceutical waste, discarded solid, liquid and gaseous chemicals from diagnostic and experimental work and from cleaning and disinfecting procedures, radioactive wastes, infectious waste, pathogen such as bacteria, viruses, parasites or fungi, needles, syringes, scalpels, infusion sets, saw, knives and blades.
Even when metastasis has begun, but is not yet evident radiologically, cancers can be cured in up to 50 percent of cases with therapies such as cytotoxic drugs and immunotherapy.
During the development of tamoxifen resistance, levels of expression and activation of several key signaling molecules such as EGFR and AKT are increased, given that increased levels of these proteins, in particularly, EGFR are generally associated with tumors that have increased resistance to cytotoxic drugs. In addition to increased expression of EGFR and c-erbB2, increased activation of these proteins was also observed, with clearly increased levels of phosphorylation of both molecules detected by Western blotting (Figure 5).
LIDDS has active development projects where NanoZolid is combined with antiandrogens, cytotoxic drugs and immuno-active agents.

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