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ThesaurusAntonymsRelated WordsSynonymsLegend: - an enzyme that removes the iodine radical
enzyme - any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions
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T4 can also become RT3 by removing the iodine from the 5-locus on the inner ring via enzyme 5 (not prime) de-iodinase or 5 Dl.
Levels of Total T3 and Free T3 suffer reduction in CKD, which is thought to be due to impairment in deiodination of T4, secondarily to decrease activity of de-iodinase enzymes.