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n. Biology
Reversion of a specialized cell or tissue to an unspecialized form. Dedifferentiation may occur before the regeneration of appendages in plants and certain animals and in the development of some cancers.

de′dif·fer·en′ti·ate′ v.
American Heritage® Dictionary of the English Language, Fifth Edition. Copyright © 2016 by Houghton Mifflin Harcourt Publishing Company. Published by Houghton Mifflin Harcourt Publishing Company. All rights reserved.


vb (intr)
to undergo the process of dedifferentiation
Collins English Dictionary – Complete and Unabridged, 12th Edition 2014 © HarperCollins Publishers 1991, 1994, 1998, 2000, 2003, 2006, 2007, 2009, 2011, 2014
ThesaurusAntonymsRelated WordsSynonymsLegend:
Verb1.dedifferentiate - lose specialization in form or function
develop - grow, progress, unfold, or evolve through a process of evolution, natural growth, differentiation, or a conducive environment; "A flower developed on the branch"; "The country developed into a mighty superpower"; "The embryo develops into a fetus"; "This situation has developed over a long time"
differentiate - become different during development; "cells differentiate"
Based on WordNet 3.0, Farlex clipart collection. © 2003-2012 Princeton University, Farlex Inc.
References in periodicals archive ?
It is also thought that malignant transformation of osteochondromas mainly in the cartilage cap develops through a stepwise fashion first into low-grade chondrosarcoma then dedifferentiates into high-grade sarcoma that may eventually become fibrosarcomas or osteosarcomas [19].
Holland, "PDGF autocrine stimulation dedifferentiates cultured astrocytes and induces oligodendrogliomas from and oligoastrocytomas neural progenitors and astrocytes in vivo," Genes and Development, vol.
With the egg cytoplasm attempting to take control of the nucleus, the skin cell apparently "dedifferentiates" and can then redifferentiate into new kinds of tissue.